Philip Wai
Philip Wai
Assistant Professor
Surgical Director, Renal Transplant
Intra-Abdominal Transplantation
Molecular Pharmacology & Therapeutics and Urology
Kidney and Pancreas Transplant, Liver Cancer, Liver Transplant, Bile Duct Disorders
Board Certifications
Surgery - General Cert: AM Board of Surgery
Guo,H.; Gao,C.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4a transcriptional activity The Biochemical journal 2014 ;461(2):347
Wai,P. Y.; Dandar,V.; Radosevich,D. M.; Brubaker,L.; Kuo,P. C.Engagement, workplace satisfaction, and retention of surgical specialists in academic medicine in the United States Journal of the American College of Surgeons 2014 ;219(1):31-42.e12
Li,N. Y.; Weber,C. E.; Mi,Z.; Wai,P. Y.; Cuevas,B. D.; Kuo,P. C.Osteopontin Up-Regulates Critical Epithelial-Mesenchymal Transition Transcription Factors to Induce an Aggressive Breast Cancer Phenotype Journal of the American College of Surgeons 2013 ; :
Weber,C. E.; Talbot,L. J.; Geller,J. M.; Kuo,M. C.; Wai,P. Y.; Kuo,P. C.Obesity and trends in malpractice claims for physicians and surgeons Surgery 2013 ; :
Li,N. Y.; Weber,C. E.; Wai,P. Y.; Cuevas,B. D.; Zhang,J.; Kuo,P. C.; Mi,Z.An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell lines Surgery 2013 ;154(2):404-410
Ellimoottil,C.; Brandt,W.; Bernardi,K.; Evans,A.; Mehta,V.; Picken,M. M.; Phelan,K.; Heinrich,L.; Milner,J.; Wai,P. Y.; Asolati,M.; Kuo,P. C.; Lu,A. D.Acute Graft Dysfunction After Living-related Renal Transplant Urology 2013 ; :
Weber,C. E.; Talbot,L. J.; Geller,J. M.; Kuo,M. C.; Wai,P. Y.; Kuo,P. C.Comparing 20 years of national general surgery malpractice claims data: obesity versus morbid obesity American Journal of Surgery 2013 ;205(3):293-7; discussion 297
Wai,P. Y.; O'Hern,T.; Andersen,D. O.; Kuo,M. C.; Weber,C. E.; Talbot,L. J.; Kuo,P. C.Impact of business infrastructure on financial metrics in departments of surgery. Surgery 2012 ;152(4):729-734
Wai,P. Y.; Kuo,P. C.Intersecting pathways in inflammation and cancer: Hepatocellular carcinoma as a paradigm World journal of clinical oncology 2012 ;3(2):15-23
Weber,C. E.; Li,N. Y.; Wai,P. Y.; Kuo,P. C.Epithelial-mesenchymal transition, TGF-beta, and osteopontin in wound healing and tissue remodeling after injury Journal of Burn Care & Research 2012 ;33(3):311-318
Bellingham,J. M.; Santhanakrishnan,C.; Neidlinger,N.; Wai,P.; Kim,J.; Niederhaus,S.; Leverson,G. E.; Fernandez,L. A.; Foley,D. P.; Mezrich,J. D.; Odorico,J. S.; Love,R. B.; De Oliveira,N.; Sollinger,H. W.; D'Alessandro,A. M.Donation after cardiac death: a 29-year experience. Surgery 2011 ;150(4):692-702
Wai,P. Y.; Sollinger,H. W.Long-term outcomes after simultaneous pancreas-kidney transplant Current Opinion in Organ Transplantation 2011 ; :128-134
Musat,A. I.; Agni,R. M.; Wai,P. Y.; Pirsch,J. D.; Lorentzen,D. F.; Powell,A.; Leverson,G. E.; Bellingham,J. M.; Fernandez,L. A.; Foley,D. P.; Mezrich,J. D.; D'Alessandro,A. M.; Lucey,M. R.The significance of donor-specific HLA antibodies in rejection and ductopenia development in ABO compatible liver transplantation. American Journal of Transplantation 2011 ;11(3):500-510
Niederhaus,S. V.; Muth,B.; Lorentzen,D. F.; Wai,P.; Pirsch,J. D.; Samaniego-Picota,M.; Leverson,G. E.; D'alessandro,A. M.; Sollinger,H. W.; Djamali,A.Luminex-based desensitization protocols: the University of Wisconsin initial experience. Transplantation 2011 ;92(1):12-17
Wai,P. Y.; Ruby,J. A.; Davis,K. A.; Roberts,A. C.; Roberts,K. E.Laparoscopic ventral hernia repair during pregnancy. Hernia 2009 ;13(5):559-563
Guo,H.; Wai,P. Y.; Mi,Z.; Gao,C.; Zhang,J.; Kuo,P. C.Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis. Surgery 2008 ;144(2):182-188
Wai,P. Y.; Kuo,P. C.Osteopontin: regulation in tumor metastasis Cancer & Metastasis Reviews 2008 ;27(1):103-118
Wai,P. Y.; Reddy,S. K.; Kuo,P. C.Functional analysis of tumor metastasis: modeling colon cancer Oncology Reviews 2008 ;2(1):9-20
Mi,Z.; Guo,H.; Wai,P. Y.; Gao,C.; Kuo,P. C.Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells. Carcinogenesis 2006 ;27(6):1134-1145
Wai,P. Y.; Guo,L.; Gao,C.; Mi,Z.; Guo,H.; Kuo,P. C.Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation. Surgery 2006 ;140(2):132-140
Wai,P. Y.; Mi,Z.; Gao,C.; Guo,H.; Marroquin,C.; Kuo,P. C.Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. Journal of Biological Chemistry 2006 ;281(28):18973-18982
Guo,H.; Gao,C.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity. Biochemical Journal 2006 ;394(Pt 2):379-387
Guo,H.; Marroquin,C. E.; Wai,P. Y.; Kuo,P. C.Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells. Digestive Diseases & Sciences 2005 ;50(7):1288-1298
Wai,P. Y.; Mi,Z.; Guo,H.; Sarraf-Yazdi,S.; Gao,C.; Wei,J.; Marroquin,C. E.; Clary,B.; Kuo,P. C.Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis. Carcinogenesis 2005 ;26(4):741-751
Gao,C.; Guo,H.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin. Journal of Immunology 2005 ;175(1):523-530
Gao,C.; Guo,H.; Wei,J.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages. Nitric Oxide 2005 ;12(2):121-126
Marroquin,C. E.; Wai,P. Y.; Kuo,P. C.; Guo,H.Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4. Surgery 2005 ;138(1):93-99
Gao,C.; Mi,Z.; Guo,H.; Wei,J.; Wai,P. Y.; Kuo,P. C.A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. Biochemical & Biophysical Research Communications 2004 ;321(4):1010-1016
Gao,C.; Guo,H.; Wei,J.; Mi,Z.; Wai,P.; Kuo,P. C.S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages. Journal of Biological Chemistry 2004 ;279(12):11236-11243
Mi,Z.; Guo,H.; Wai,P. Y.; Gao,C.; Wei,J.; Kuo,P. C.Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior. Journal of Biological Chemistry 2004 ;279(45):46659-46667
Wai,P. Y.; Kuo,P. C.The role of Osteopontin in tumor metastasis Journal of Surgical Research 2004 ;121(2):228-241
Wai,P. H.; Ewing,C. A.; Johnson,L. B.; Lu,A. D.; Attinger,C.; Kuo,P. C.Candida fasciitis following renal transplantation Transplantation 2001 ;72(3):477-479
Medical School
Georgetown University School of Medicine
Yale University School of Medicine/New Haven Hospital, General Surgery
Yale University School of Medicine/New Haven Hospital, General Surgery
University of Wisconsin Hospital and Clinics, Transplant Surgery