Paul C. Kuo
John P. Igini, M.D., Professor of Surgery
Department Chairperson, Surgery
Director, Oncology Institute
Surgical Oncology
Molecular Pharmacology and Therapeutics
Liver Transplant, Bile Duct Cancer, Hernia, Gallbladder Disorders, Minimally Invasive Surgery, Liver Cancer, Liver Disorders, Bile Duct Disorders, Gastroesophageal Reflux (GERD), Gastrointestinal Surgery
Board Certifications
Clinical Informatics - Subspecialty: AM Board of Preventive Medicine
Surgery - General Cert: AM Board of Surgery
Surgical Critical Care - Subspecialty Cert: AM Board of Surgery
Blackwell,R. H.; Ellimoottil,C.; Bajic,P.; Kothari,A.; Zapf,M.; Kliethermes,S.; Flanigan,R. C.; Quek,M. L.; Kuo,P. C.; Gupta,G. N.New Onset Postoperative Atrial Fibrillation Predicts Long-Term Cardiovascular Events Following Radical Cystectomy The Journal of urology 2015 ; :
You,D.; Xin,J.; Volk,A.; Wei,W.; Schmidt,R.; Scurti,G.; Nand,S.; Breuer,E. K.; Kuo,P. C.; Breslin,P.; Kini,A. R.; Nishimura,M. I.; Zeleznik-Le,N. J.; Zhang,J.FAK Mediates a Compensatory Survival Signal Parallel to PI3K-AKT in PTEN-Null T-ALL Cells Cell reports 2015 ;10(12):2055-2068
Li,N. Y.; Tong,L.; Barbas,A. S.; Bhattacharya,S. D.; Wai,P. Y.; Kuo,P. C.Renal response following perioperative ketorolac analgesia in living kidney donation Transplantation 2015 ;99(3):e22-3
Driver,J.; Weber,C. E.; Callaci,J. J.; Kothari,A. N.; Zapf,M. A.; Roper,P. M.; Borys,D.; Franzen,C. A.; Gupta,G. N.; Wai,P. Y.; Zhang,J.; Denning,M. F.; Kuo,P. C.; Mi,Z.Alcohol Inhibits Osteopontin Dependent Transforming Growth Factor-beta1 Expression in Human Mesenchymal Stem Cells The Journal of biological chemistry 2015 ; :
Kothari,A. N.; Mi,Z.; Zapf,M.; Kuo,P. C.Novel clinical therapeutics targeting the epithelial to mesenchymal transition Clinical and translational medicine 2014 ;3:35-014-0035-0. eCollection 2014
Choi,S. S.; Claridge,L. C.; Jhaveri,R.; Swiderska-Syn,M.; Clark,P.; Suzuki,A.; Pereira,T. A.; Mi,Z.; Kuo,P. C.; Guy,C. D.; Pereira,F. E.; Diehl,A. M.; Patel,K.; Syn,W. K.Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication Clinical science (London, England : 1979) 2014 ;126(12):845-855
Franzen,C. A.; Simms,P. E.; Van Huis,A. F.; Foreman,K. E.; Kuo,P. C.; Gupta,G. N.Characterization of uptake and internalization of exosomes by bladder cancer cells BioMed research international 2014 ;2014:619829
Wai,P. Y.; Dandar,V.; Radosevich,D. M.; Brubaker,L.; Kuo,P. C.Engagement, workplace satisfaction, and retention of surgical specialists in academic medicine in the United States Journal of the American College of Surgeons 2014 ;219(1):31-42.e12
Weber,C. E.; Kothari,A. N.; Wai,P. Y.; Li,N. Y.; Driver,J.; Zapf,M. A.; Franzen,C. A.; Gupta,G. N.; Osipo,C.; Zlobin,A.; Syn,W. K.; Zhang,J.; Kuo,P. C.; Mi,Z.Osteopontin mediates an MZF1-TGF-beta1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer Oncogene 2014 ; :
Guo,H.; Gao,C.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4a transcriptional activity The Biochemical journal 2014 ;461(2):347
Chang,V.; Kuo,P. C.; Wai,P. Y.Doing well by doing good: linking access with quality American Journal of Surgery 2014 ; :
Coombes,J. D.; Swiderska-Syn,M.; Dolle,L.; Reid,D.; Eksteen,B.; Claridge,L.; Briones-Orta,M. A.; Shetty,S.; Oo,Y. H.; Riva,A.; Chokshi,S.; Papa,S.; Mi,Z.; Kuo,P. C.; Williams,R.; Canbay,A.; Adams,D. H.; Diehl,A. M.; van Grunsven,L. A.; Choi,S. S.; Syn,W. K.Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice Gut 2014 ; :
Weber,C. E.; Talbot,L. J.; Geller,J. M.; Kuo,M. C.; Wai,P. Y.; Kuo,P. C.Comparing 20 years of national general surgery malpractice claims data: obesity versus morbid obesity American Journal of Surgery 2013 ;205(3):293-7; discussion 297
Ellimoottil,C.; Brandt,W.; Bernardi,K.; Evans,A.; Mehta,V.; Picken,M. M.; Phelan,K.; Heinrich,L.; Milner,J.; Wai,P. Y.; Asolati,M.; Kuo,P. C.; Lu,A. D.Acute Graft Dysfunction After Living-related Renal Transplant Urology 2013 ; :
Li,N. Y.; Weber,C. E.; Mi,Z.; Wai,P. Y.; Cuevas,B. D.; Kuo,P. C.Osteopontin Up-Regulates Critical Epithelial-Mesenchymal Transition Transcription Factors to Induce an Aggressive Breast Cancer Phenotype Journal of the American College of Surgeons 2013 ; :
Li,N. Y.; Weber,C. E.; Wai,P. Y.; Cuevas,B. D.; Zhang,J.; Kuo,P. C.; Mi,Z.An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell lines Surgery 2013 ;154(2):404-410
Weber,C. E.; Talbot,L. J.; Geller,J. M.; Kuo,M. C.; Wai,P. Y.; Kuo,P. C.Obesity and trends in malpractice claims for physicians and surgeons Surgery 2013 ; :
Jing,Y. H.; Chen,K. H.; Kuo,P. C.; Pao,C. C.; Chen,J. K.Neurodegeneration in Streptozotocin-Induced Diabetic Rats is Attenuated by Treatment with Resveratrol Neuroendocrinology 2013 ; :
Hsueh,Y. J.; Kuo,P. C.; Chen,J. K.Transcriptional regulators of the DeltaNp63: their role in limbal epithelial cell proliferation Journal of cellular physiology 2013 ;228(3):536-546
Foreman,K. E.; Jesse,J. N.,3rd; Kuo,P. C.; Gupta,G. N.Emetine Dihydrochloride: A Novel Therapy for Bladder Cancer The Journal of urology 2013 ; :
Mehta,A.; Baker,T. A.; Shoup,M.; Brownson,K.; Amde,S.; Doren,E.; Shah,S.; Kuo,P.; Angelats,J.Biplanar flap reconstruction for pressure ulcers: experience in patients with immobility from chronic spinal cord injuries American Journal of Surgery 2012 ;203(3):303-307
Wai,P. Y.; O'Hern,T.; Andersen,D. O.; Kuo,M. C.; Weber,C. E.; Talbot,L. J.; Kuo,P. C.Impact of business infrastructure on financial metrics in departments of surgery. Surgery 2012 ;152(4):729-734
Wai,P. Y.; Kuo,P. C.Intersecting pathways in inflammation and cancer: Hepatocellular carcinoma as a paradigm World journal of clinical oncology 2012 ;3(2):15-23
Hunter,C.; Bond,J.; Kuo,P. C.; Selim,M. A.; Levinson,H.The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity The Journal of surgical research 2012 ;176(1):348-358
Bhattacharya,S. D.; Mi,Z.; Kim,V. M.; Guo,H.; Talbot,L. J.; Kuo,P. C.Osteopontin regulates epithelial mesenchymal transition-associated growth of hepatocellular cancer in a mouse xenograft model Annals of Surgery 2012 ;255(2):319-325
Bhattacharya,S. D.; Mi,Z.; Talbot,L. J.; Guo,H.; Kuo,P. C.Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers Surgery 2012 ;152(3):449-454
Weber,C. E.; Kuo,P. C.The tumor microenvironment Surgical oncology 2012 ;21(3):172-177
Weber,C. E.; Li,N. Y.; Wai,P. Y.; Kuo,P. C.Epithelial-mesenchymal transition, TGF-beta, and osteopontin in wound healing and tissue remodeling after injury Journal of Burn Care & Research 2012 ;33(3):311-318
Fisichella,P. M.; Pittman,M.; Kuo,P. C.Laparoscopic Treatment of Epiphrenic Diverticula: Preoperative Evaluation and Surgical Technique. How I Do It Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2011 ;15(10):1861-71
Fisichella,P. M.; Davis,C. S.; Lundberg,P. W.; Lowery,E.; Burnham,E. L.; Alex,C. G.; Ramirez,L.; Pelletiere,K.; Love,R. B.; Kuo,P. C.; Kovacs,E. J.The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Surgery 2011 ;150(4):598-606
Aggarwal,H.; Smith,A. D.; Kuo,P. C.; Vikraman,D. S.Streptococcus equi primary bacteremia in a hepatitis-C cirrhotic patient. Transplantation 2009 ;87(5):783
Mi,Z.; Guo,H.; Kuo,P. C.Identification of osteopontin-dependent signaling pathways in a mouse model of human breast cancer BMC research notes 2009 ;2:119-0500-2-119
Mi,Z.; Guo,H.; Russell,M. B.; Liu,Y.; Sullenger,B. A.; Kuo,P. C.RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells. Molecular Therapy: the Journal of the American Society of Gene Therapy 2009 ;17(1):153-161
Zhang,J.; Guo,H.; Mi,Z.; Gao,C.; Bhattacharya,S.; Li,J.; Kuo,P. C.EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells. Experimental cell research 2009 ;315(2):304-312
Scarborough,J. E.; Bennett,K. M.; Schroeder,R. A.; Swedish,T. B.; Jacobs,D. O.; Kuo,P. C.Will the clinicians support the researchers and teachers? Results of a salary satisfaction survey of 947 academic surgeons. Annals of Surgery 2009 ;250(3):432-439
Wai,P. Y.; Kuo,P. C.Osteopontin: regulation in tumor metastasis Cancer & Metastasis Reviews 2008 ;27(1):103-118
Wai,P. Y.; Reddy,S. K.; Kuo,P. C.Functional analysis of tumor metastasis: modeling colon cancer Oncology Reviews 2008 ;2(1):9-20
Scarborough,J. E.; Pietrobon,R.; Bennett,K. M.; Clary,B. M.; Kuo,P. C.; Tyler,D. S.; Pappas,T. N.Workforce projections for hepato-pancreato-biliary surgery. Journal of the American College of Surgeons 2008 ;206(4):678-684
Scarborough,J. E.; Pietrobon,R.; Clary,B. M.; Marroquin,C. E.; Bennett,K. M.; Kuo,P. C.; Pappas,T. N.Regionalization of hepatic resections is associated with increasing disparities among some patient populations in use of high-volume providers. Journal of the American College of Surgeons 2008 ;207(6):831-838
Schroeder,R. A.; Kuo,P. C.Pro: low central venous pressure during liver transplantation--not too low Journal of Cardiothoracic & Vascular Anesthesia 2008 ;22(2):311-314
Scarborough,J. E.; Pietrobon,R.; Tuttle-Newhall,J. E.; Marroquin,C. E.; Collins,B. H.; Desai,D. M.; Kuo,P. C.; Pappas,T. N.Relationship between provider volume and outcomes for orthotopic liver transplantation. Journal of Gastrointestinal Surgery 2008 ;12(9):1527-1533
Scarborough,J. E.; Tuttle-Newhall,J. E.; Pietrobon,R.; Marroquin,C. E.; Collins,B. H.; Desai,D. M.; Kuo,P. C.; Pappas,T. N.Supply and demand for liver transplant surgery: are we training enough surgeons?. HPB 2008 ;10(1):25-29
Takami,Y.; Higashi,M.; Kumagai,S.; Kuo,P. C.; Kawana,H.; Koda,K.; Miyazaki,M.; Harigaya,K.The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer. Digestive Diseases & Sciences 2008 ;53(2):467-473
Kuo,P. C.; Schroeder,R. A.; Shah,A.; Shah,J.; Jacobs,D. O.; Pietrobon,R."Ghost" publications among applicants to a general surgery residency program. Journal of the American College of Surgeons 2008 ;207(4):485-489
Emani,S.; Zhang,J.; Guo,L.; Guo,H.; Kuo,P. C.RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer. Surgery 2008 ;143(6):803-812
Guo,H.; Mi,Z.; Kuo,P. C.Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene. Journal of Biological Chemistry 2008 ;283(37):25209-25217
Guo,H.; Wai,P. Y.; Mi,Z.; Gao,C.; Zhang,J.; Kuo,P. C.Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis. Surgery 2008 ;144(2):182-188
Alexander,J. W.; Goodman,H. R.; Succop,P.; Light,J. A.; Kuo,P. C.; Moser,A. B.; James,J. H.; Woodle,E. S.Influence of long chain polyunsaturated fatty acids and ornithine concentrations on complications after renal transplant. Experimental & Clinical Transplantation: Official Journal of the Middle East Society for Organ Transplantation 2008 ;6(2):118-126
Reddy,S. K.; Barbas,A. S.; Marroquin,C. E.; Morse,M. A.; Kuo,P. C.; Clary,B. M.Resection of noncolorectal nonneuroendocrine liver metastases: a comparative analysis. Journal of the American College of Surgeons 2007 ;204(3):372-382
Reddy,S. K.; Marroquin,C. E.; Kuo,P. C.; Pappas,T. N.; Clary,B. M.Extended hepatic resection for gallbladder cancer. American Journal of Surgery 2007 ;194(3):355-361
Guo,H.; Gao,C.; Mi,Z.; Zhang,J.; Kuo,P. C.Characterization of the PC4 binding domain and its interactions with HNF4alpha. Journal of Biochemistry 2007 ;141(5):635-640
Gao,C.; Guo,H.; Mi,Z.; Grusby,M. J.; Kuo,P. C.Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. Journal of Immunology 2007 ;178(3):1870-1881
Gao,C.; Mi,Z.; Guo,H.; Kuo,P. C.Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells. Neoplasia (New York) 2007 ;9(9):699-706
Cibrik,D.; Meier-Kriesche,H. U.; Bresnahan,B.; Wu,Y. M.; Klintmalm,G.; Kew,C. E.; Kuo,P. C.; Whelchel,J.; Cohen,D.; Baliga,P.; Akalin,E.; Benedetti,E.; Wright,F.; Lieberman,B.; Ulbricht,B.; Jensik,S.; Myfortic-US01 Renal Transplant Study,GroupRenal function with cyclosporine C2 monitoring, enteric-coated mycophenolate sodium and basiliximab: a 12-month randomized trial in renal transplant recipients. Clinical transplantation 2007 ;21(2):192-201
Takami,Y.; Russell,M. B.; Gao,C.; Mi,Z.; Guo,H.; Mantyh,C. R.; Kuo,P. C.Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells. Surgery 2007 ;142(2):163-169
Guo,L.; Guo,H.; Gao,C.; Mi,Z.; Russell,W. B.; Kuo,P. C.Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-gamma-treated RAW264.7 murine macrophages. Surgery 2007 ;142(2):156-162
Silva,H. T.,Jr; Yang,H. C.; Abouljoud,M.; Kuo,P. C.; Wisemandle,K.; Bhattacharya,P.; Dhadda,S.; Holman,J.; Fitzsimmons,W.; First,M. R.One-year results with extended-release tacrolimus/MMF, tacrolimus/MMF and cyclosporine/MMF in de novo kidney transplant recipients American Journal of Transplantation 2007 ;7(3):595-608
Shah,A.; Pietrobon,R.; Cook,C.; Sheth,N. P.; Nguyen,L.; Guo,L.; Jacobs,D. O.; Kuo,P. C.Little science, big science: strategies for research portfolio selection in academic surgery departments. Annals of Surgery 2007 ;246(6):1110-1115
Mi,Z.; Oliver,T.; Guo,H.; Gao,C.; Kuo,P. C.Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells. Cancer research 2007 ;67(9):4088-4097
Scarborough,J. E.; Pietrobon,R.; Marroquin,C. E.; Tuttle-Newhall,J. E.; Kuo,P. C.; Collins,B. H.; Desai,D. M.; Pappas,T. N.Temporal trends in early clinical outcomes and health care resource utilization for liver transplantation in the United States. Journal of Gastrointestinal Surgery 2007 ;11(1):82-88
Palmer,S. M.; Burch,L. H.; Mir,S.; Smith,S. R.; Kuo,P. C.; Herczyk,W. F.; Reinsmoen,N. L.; Schwartz,D. A.Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation. Clinical transplantation 2006 ;20(1):30-36
Kuo,P. C.Clinical performance feedback is necessary but not sufficient for longterm success of the academic department of surgery. Journal of the American College of Surgeons 2006 ;203(3):402-403
Wai,P. Y.; Guo,L.; Gao,C.; Mi,Z.; Guo,H.; Kuo,P. C.Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation. Surgery 2006 ;140(2):132-140
Wai,P. Y.; Mi,Z.; Gao,C.; Guo,H.; Marroquin,C.; Kuo,P. C.Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. Journal of Biological Chemistry 2006 ;281(28):18973-18982
Schroeder,R. A.; Marroquin,C. E.; Bute,B. P.; Khuri,S.; Henderson,W. G.; Kuo,P. C.Predictive indices of morbidity and mortality after liver resection. Annals of Surgery 2006 ;243(3):373-379
Guo,H.; Gao,C.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity. Biochemical Journal 2006 ;394(Pt 2):379-387
Mi,Z.; Guo,H.; Wai,P. Y.; Gao,C.; Kuo,P. C.Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells. Carcinogenesis 2006 ;27(6):1134-1145
Day,T. E.; Napoli,J. T.; Kuo,P. C.Scheduling the resident 80-hour work week: an operations research algorithm. Current surgery 2006 ;63(2):136-141
Gable,W. H.; Pappas,T. N.; Jacobs,D. O.; Cutler,D. A.; Kuo,P. C.Productivity measures associated with a patient access initiative. Annals of Surgery 2006 ;243(5):604-609
Desai,D. M.; Kuo,P. C.Who should perform liver transplantation? Should that be the transplant surgeon, the hepatobilary surgeon, or the general surgeon? Part I: the transplant surgeon. Journal of Hepatology 2006 ;44(4):647-649
Desai,D. M.; Kuo,P. C.Perioperative management of special populations: immunocompromised host (cancer, HIV, transplantation) Surgical Clinics of North America 2005 ;85(6):1267-1282
Gao,C.; Guo,H.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin. Journal of Immunology 2005 ;175(1):523-530
Gao,C.; Guo,H.; Wei,J.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages. Nitric Oxide 2005 ;12(2):121-126
Hanish,S. I.; Petersen,R. P.; Collins,B. H.; Tuttle-Newhall,J.; Marroquin,C. E.; Kuo,P. C.; Butterly,D. W.; Smith,S. R.; Desai,D. M.Obesity predicts increased overall complications following pancreas transplantation. Transplantation proceedings 2005 ;37(8):3564-3566
Guo,H.; Marroquin,C. E.; Wai,P. Y.; Kuo,P. C.Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells. Digestive Diseases & Sciences 2005 ;50(7):1288-1298
Wai,P. Y.; Mi,Z.; Guo,H.; Sarraf-Yazdi,S.; Gao,C.; Wei,J.; Marroquin,C. E.; Clary,B.; Kuo,P. C.Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis. Carcinogenesis 2005 ;26(4):741-751
Marroquin,C. E.; Edwards,E. B.; Collins,B. H.; Desai,D. M.; Tuttle-Newhall,J. E.; Kuo,P. C.Half-life analysis of pancreas and kidney transplants. Transplantation 2005 ;80(2):272-275
Marroquin,C. E.; Wai,P. Y.; Kuo,P. C.; Guo,H.Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4. Surgery 2005 ;138(1):93-99
Collins,B. H.; Marroquin,C. E.; Tuttle-Newhall,J. E.; Kuo,P. C.; Preminger,G. M.; Butterly,D. W.Acute kidney transplant failure following transurethral bladder polyp fulguration. Journal of the National Medical Association 2005 ;97(3):414-416
Tuttle-Newhall,J. E.; Collins,B. H.; Desai,D. M.; Kuo,P. C.; Heneghan,M. A.The current status of living donor liver transplantation Current problems in surgery 2005 ;42(3):144-183
Smith,A. D.; Bai,D.; Marroquin,C. E.; Tuttle-Newhall,J. E.; Desai,D. M.; Collins,B. H.; Muir,A.; Kuo,P. C.; McHutchison,J.; Rockey,D. C.Gastrointestinal hemorrhage due to complicated gastroduodenal ulcer disease in liver transplant patients taking sirolimus. Clinical transplantation 2005 ;19(2):250-254
Smith,A. D.; Morse,M. A.; Kuo,P. C.Case 23-2005: a man with a mass in the liver. New England Journal of Medicine 2005 ;353(20):2195-2197
Huang,E. S.; Nevins,J. R.; West,M.; Kuo,P. C.An overview of genomic data analysis. Surgery 2004 ;136(3):497-499
Kuo,P. C.; Douglas,A. R.; Oleski,D.; Jacobs,D. O.; Schroeder,R. A.Determining benchmarks for evaluation and management coding in an academic division of general surgery. Journal of the American College of Surgeons 2004 ;199(1):124-130
Marroquin,C. E.; Downey,L.; Guo,H.; Kuo,P. C.Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells. Immunology letters 2004 ;95(1):109-112
Wei,J.; Guo,H.; Gao,C.; Kuo,P. C.Peroxide-mediated chromatin remodelling of a nuclear factor kappa B site in the mouse inducible nitric oxide synthase promoter. Biochemical Journal 2004 ;377(Pt 3):809-818
Wai,P. Y.; Kuo,P. C.The role of Osteopontin in tumor metastasis Journal of Surgical Research 2004 ;121(2):228-241
Schroeder,R. A.; Collins,B. H.; Tuttle-Newhall,E.; Robertson,K.; Plotkin,J.; Johnson,L. B.; Kuo,P. C.Intraoperative fluid management during orthotopic liver transplantation. Journal of Cardiothoracic & Vascular Anesthesia 2004 ;18(4):438-441
Gao,C.; Mi,Z.; Guo,H.; Wei,J.; Wai,P. Y.; Kuo,P. C.A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. Biochemical & Biophysical Research Communications 2004 ;321(4):1010-1016
Mi,Z.; Guo,H.; Wai,P. Y.; Gao,C.; Wei,J.; Kuo,P. C.Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior. Journal of Biological Chemistry 2004 ;279(45):46659-46667
Gao,C.; Guo,H.; Wei,J.; Mi,Z.; Wai,P.; Kuo,P. C.S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages. Journal of Biological Chemistry 2004 ;279(12):11236-11243
Schroeder,R. A.; Marroquin,C. E.; Kuo,P. C.Tolerance and the "Holy Grail" of transplantation Journal of Surgical Research 2003 ;111(1):109-119
Gao,C.; Guo,H.; Downey,L.; Marroquin,C.; Wei,J.; Kuo,P. C.Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells. Carcinogenesis 2003 ;24(12):1871-1878
Gao,C.; Guo,H.; Wei,J.; Kuo,P. C.Osteopontin inhibits expression of cytochrome c oxidase in RAW 264.7 murine macrophages. Biochemical & Biophysical Research Communications 2003 ;309(1):120-125
Rocha,P. N.; Butterly,D. W.; Greenberg,A.; Reddan,D. N.; Tuttle-Newhall,J.; Collins,B. H.; Kuo,P. C.; Reinsmoen,N.; Fields,T.; Howell,D. N.; Smith,S. R.Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection. Transplantation 2003 ;75(9):1490-1495
Marroquin,C. E.; Tuttle-Newhall,J. E.; Collins,B. H.; Kuo,P. C.; Schroeder,R. A.Emergencies after liver transplantation. Seminars in gastrointestinal disease 2003 ;14(2):101-110
Tuttle-Newhall,J. E.; Collins,B. H.; Kuo,P. C.; Schoeder,R.Organ donation and treatment of the multi-organ donor Current problems in surgery 2003 ;40(5):266-310
Heneghan,M. A.; Tuttle-Newhall,J. E.; Suhocki,P. V.; Muir,A. J.; Morse,M.; Bornstein,J. D.; Sylvestre,P. B.; Collins,B.; Kuo,P. C.; Rockey,D. C.De-novo cholangiocarcinoma in the setting of recurrent primary sclerosing cholangitis following liver transplant. American Journal of Transplantation 2003 ;3(5):634-638
Kuo,P. C.; Schroeder,R. A.; Mahaffey,S.; Bollinger,R. R.Optimization of operating room allocation using linear programming techniques. Journal of the American College of Surgeons 2003 ;197(6):889-895
Dy-Liacco,M. S.; Tuttle-Newhall,E. J.; Collins,B. H.; Kuo,P. C.Liver transplantation from a cadaver donor with ethylene-glycol-induced brain death. Transplantation 2003 ;75(7):1056
Guo,H.; Wei,J.; Inoue,Y.; Gonzalez,F. J.; Kuo,P. C.Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. American Journal of Physiology - Cell Physiology 2003 ;284(4):1090-1099
Buell,J. F.; Hanaway,M. J.; Potter,S. R.; Koffron,A.; Kuo,P. C.; Leventhal,J.; Cho,E.; Johnson,M.; Edye,M.; Woodle,E. S.Surgical techniques in right laparoscopic donor nephrectomy. Journal of the American College of Surgeons 2002 ;195(1):131-137
Guo,H.; Cai,C. Q.; Kuo,P. C.Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. Journal of Biological Chemistry 2002 ;277(7):5054-5060
Guo,H. T.; Cai,C. Q.; Schroeder,R. A.; Kuo,P. C.Nitric oxide is necessary for CC-class chemokine expression in endotoxin-stimulated ANA-1 murine macrophages. Immunology letters 2002 ;80(1):21-26
Wei,J.; Guo,H.; Kuo,P. C.Endotoxin-stimulated nitric oxide production inhibits expression of cytochrome c oxidase in ANA-1 murine macrophages. Journal of Immunology 2002 ;168(9):4721-4727
Marino,G.; Rustgi,V. K.; Salzberg,G.; Johnson,L. B.; Kuo,P. C.; Plotkin,J. S.; Flockhart,D. A.Pharmacokinetics and biochemical effects of hepapoietin in patients with chronic liver disease. Alimentary Pharmacology & Therapeutics 2002 ;16(2):235-242
Muir,A. J.; Sanders,L. L.; Heneghan,M. A.; Kuo,P. C.; Wilkinson,W. E.; Provenzale,D.An examination of factors predicting prioritization for liver transplantation. Liver Transplantation 2002 ;8(10):957-961
Jha,R. C.; Korangy,S. J.; Ascher,S. M.; Takahama,J.; Kuo,P. C.; Johnson,L. B.MR angiography and preoperative evaluation for laparoscopic donor nephrectomy. AJR.American Journal of Roentgenology 2002 ;178(6):1489-1495
Marroquin,C. E.; Marino,G.; Kuo,P. C.; Plotkin,J. S.; Rustgi,V. K.; Lu,A. D.; Edwards,E.; Taranto,S.; Johnson,L. B.Transplantation of hepatitis C-positive livers in hepatitis C-positive patients is equivalent to transplanting hepatitis C-negative livers. Liver Transplantation 2001 ;7(9):762-768
Plotkin,J. S.; Johnson,L. B.; Rustgi,V. K.; Kuo,P. C.; Lu,A. D.Dobutamine stress echocardiography for orthotopic liver transplant evaluation. Transplantation 2001 ;71(6):818
Wai,P. H.; Ewing,C. A.; Johnson,L. B.; Lu,A. D.; Attinger,C.; Kuo,P. C.Candida fasciitis following renal transplantation Transplantation 2001 ;72(3):477-479
Kuo,P. C.Reconsideration of HIV as a contraindication to transplantation. Transplantation 2001 ;71(11):1689
Kuo,P. C.; Lu,A. D.; Johnson,L. B.Expanded criteria donors/high risk recipients is not always cheaper than hemodialysis. Transplantation 2001 ;72(3):554-555
Kuo,P. C.; Stock,P. G.Transplantation in the HIV+ patient American Journal of Transplantation 2001 ;1(1):13-17
Cappadonna,C. R.; Johnson,L. B.; Lu,A. D.; Kuo,P. C.Outcome of extra-anatomic vascular reconstruction in orthotopic liver transplantation. American Journal of Surgery 2001 ;182(2):147-150
Guo,H.; Cai,C. Q.; Schroeder,R. A.; Kuo,P. C.Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages. Journal of Immunology 2001 ;166(2):1079-1086
Buell,J. F.; Edye,M.; Johnson,M.; Li,C.; Koffron,A.; Cho,E.; Kuo,P.; Johnson,L.; Hanaway,M.; Potter,S. R.; Bruce,D. S.; Cronin,D. C.; Newell,K. A.; Leventhal,J.; Jacobs,S.; Woodle,E. S.; Bartlett,S. T.; Flowers,J. L.Are concerns over right laparoscopic donor nephrectomy unwarranted?. Annals of Surgery 2001 ;233(5):645-651
Guo,H.; Wei,J.; Kuo,P. C.Nitric oxide inhibits expression of cytochrome B in endotoxin-stimulated murine macrophages. Biochemical & Biophysical Research Communications 2001 ;289(5):993-997
Guo,H. T.; Cai,C. Q.; Kuo,P. C.Endotoxin and NO induce MIP-1gamma gene transcription in ANA-1 murine macrophages. Biochemical & Biophysical Research Communications 2000 ;277(3):617-621
Kuo,P. C.; Abe,K.; Schroeder,R. A.Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene Gastroenterology 2000 ;118(3):608-618
Medical School
Johns Hopkins University School of Medicine
Brigham and Women's Hospital, General Surgery
Beth Israel Deaconess Medical Center/Harvard University Medical School, Transplant/Hepatobiliary Surgery