David J. Wilber
George M. Eisenberg Professor of Cardiovascular Sciences
Co-Director, Cardiovascular Research Institute
Director, Cardiovascular Institute
Division Director, Cardiology
Medical Director, Clinical Electrophysiology
Pediatric Cardiology
Ablation of Atrial Fibrillation, Alternatives to Anticoagulation for AF, Heart Failure; Arrhythmias, Electrophysiology, Ablation Catheter Applications for Complex Arrhythmias
Board Certifications
Cardiovascular Disease - Subspecialty Cert: AM Board of Internal Medicine
Clinical Cardiac Electrophysiology - Subspecialty Cert: AM Board of Internal Medicine
Internal Medicine - General Cert: AM Board of Internal Medicine
Hirai,T.; Cotseones,G.; Makki,N.; Agrawal,A.; Wilber,D. J.; Barron,J. T.Usefulness of Left Ventricular Diastolic Function to Predict Recurrence of Atrial Fibrillation in Patients With Preserved Left Ventricular Systolic Function The American Journal of Cardiology 2014 ; :
Natale,A.; Reddy,V. Y.; Monir,G.; Wilber,D. J.; Lindsay,B. D.; McElderry,H. T.; Kantipudi,C.; Mansour,M. C.; Melby,D. P.; Packer,D. L.; Nakagawa,H.; Zhang,B.; Stagg,R. B.; Boo,L. M.; Marchlinski,F. E.Paroxysmal AF Catheter Ablation With a Contact Force Sensing Catheter: Results of the Prospective, Multicenter SMART-AF Trial Journal of the American College of Cardiology 2014 ;64(7):647-656
Marrouche,N. F.; Wilber,D.; Hindricks,G.; Jais,P.; Akoum,N.; Marchlinski,F.; Kholmovski,E.; Burgon,N.; Hu,N.; Mont,L.; Deneke,T.; Duytschaever,M.; Neumann,T.; Mansour,M.; Mahnkopf,C.; Herweg,B.; Daoud,E.; Wissner,E.; Bansmann,P.; Brachmann,J.Association of atrial tissue fibrosis identified by delayed enhancement MRI and atrial fibrillation catheter ablation: the DECAAF study JAMA : the journal of the American Medical Association 2014 ;311(5):498-506
Goldenberg,I.; Kutyifa,V.; Klein,H. U.; Cannom,D. S.; Brown,M. W.; Dan,A.; Daubert,J. P.; Estes,N. A.,3rd; Foster,E.; Greenberg,H.; Kautzner,J.; Klempfner,R.; Kuniss,M.; Merkely,B.; Pfeffer,M. A.; Quesada,A.; Viskin,S.; McNitt,S.; Polonsky,B.; Ghanem,A.; Solomon,S. D.; Wilber,D.; Zareba,W.; Moss,A. J.Survival with Cardiac-Resynchronization Therapy in Mild Heart Failure The New England journal of medicine 2014 ; :
Ruwald,A. C.; Schuger,C.; Moss,A. J.; Kutyifa,V.; Olshansky,B.; Greenberg,H.; Cannom,D. S.; Estes,N. A.,3rd; Ruwald,M. H.; Huang,D. T.; Klein,H.; McNitt,S.; Beck,C. A.; Goldstein,R.; Brown,M. W.; Kautzner,J.; Shoda,M.; Wilber,D.; Zareba,W.; Daubert,J. P.Mortality Reduction In Relation To ICD Programming In MADIT-RIT Circulation.Arrhythmia and electrophysiology 2014 ; :
Nguyen,B.; Fennessy,M.; Leya,F.; Nowak,W.; Ryan,M.; Freeberg,S.; Gill,J.; Dieter,R. S.; Steen,L.; Lewis,B.; Cichon,M.; Probst,B.; Jarotkiewicz,M.; Wilber,D.; Lopez,J. J.Comparison of primary percutaneous coronary intervention in patients with st-elevation myocardial infarction during and prior to availability of an in-house STEMI system: Early experience and intermediate outcomes of the HARRT program for achieving routine d2b times <60 minutes Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2014 ; :
Wilber,D. J.Ablation of the Epicardial Substrate in Ventricular Tachycardia Associated with Structural Heart Disease: Outside In or Inside Out? Journal of the American College of Cardiology 2014 ; :
Winterfield,J. R.; Mahapatra,S.; Wilber,D. J.Catheter ablation of ventricular arrhythmias: targets, tactics, and tools CURRENT OPINION IN CARDIOLOGY 2013 ;28(3):344-353
Bashir,A.; Rabbat,M.; Biswas,S.; Wilber,D.; Sanagala,T.; Syed,M. A.Left atrial volume assessment by area-length method compared to multislice volumetric method using cardiovascular magnetic resonance imaging Journal of Cardiovascular Magnetic Resonance (BioMed Central) 2013 ;15:1-2
Biswas,S.; Sanagala,T.; Wilber,D.; Syed,M. A.Comparison of two methods of right atrial volume assessment using cardiac magnetic resonance imaging: area-length method versus multislice volumetric method Journal of Cardiovascular Magnetic Resonance (BioMed Central) 2013 ;15:1-2
Waldo,A. L.; Wilber,D. J.; Marchlinski,F. E.; Stevenson,W. G.; Aker,B.; Boo,L. M.; Jackman,W. M.Safety of the Open-Irrigated Ablation Catheter for Radiofrequency Ablation: Safety Analysis from Six Clinical Studies Pacing & Clinical Electrophysiology 2012 ;35(9):1081-1089
Raviele,A.; Natale,A.; Calkins,H.; Camm,J. A.; Cappato,R.; Ann Chen,S.; Connolly,S. J.; Damiano Jr,R.; De Ponti,R.; Edgerton,J. R.; Haissaguerre,M.; Hindricks,G.; Ho,S. Y.; Jalife,J.; Kirchhof,P.; Kottkamp,H.; Kuck,K. H.; Marchlinski,F. E.; Packer,D. L.; Pappone,C.; Prystowsky,E.; Reddy,V. K.; Themistoclakis,S.; Verma,A.; Wilber,D. J.; Willems,S.Venice Chart International Consensus Document on Atrial Fibrillation Ablation: 2011 Update Journal of cardiovascular electrophysiology 2012 ;23(8):890-923
Wilber,D. J.Fibroblasts, focal triggers, and persistent atrial fibrillation: is there a connection? Circulation: Arrhythmia & Electrophysiology 2012 ;5(2):249-251
Verma,A.; Sanders,P.; Macle,L.; Champagne,J.; Nair,G. M.; Calkins,H.; Wilber,D. J.Selective CFAE Targeting for Atrial Fibrillation Study (SELECT AF): Clinical Rationale, Design, and Implementation Journal of cardiovascular electrophysiology 2011 ;22(5):541-547
Asimaki,A.; Tandri,H.; Duffy,E. R.; Winterfield,J. R.; Mackey-Bojack,S.; Picken,M. M.; Cooper,L. T.; Wilber,D. J.; Marcus,F. I.; Basso,C.; Thiene,G.; Tsatsopoulou,A.; Protonotarios,N.; Stevenson,W. G.; McKenna,W. J.; Gautam,S.; Remick,D. G.; Calkins,H.; Saffitz,J. E.Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy Circulation.Arrhythmia and electrophysiology 2011 ;4(5):743-752
Al Chekakie,M. O.; Welles,C. C.; Metoyer,R.; Ibrahim,A.; Shapira,A. R.; Cytron,J.; Santucci,P.; Wilber,D. J.; Akar,J. G.Pericardial fat is independently associated with human atrial fibrillation. Journal of the American College of Cardiology 2010 ;56(10):784-788
Wilber,D. J.DeCFAEnating atrial fibrillation: narrowing the targets... complex and/or fractionated atrial electrogram Journal of cardiovascular electrophysiology 2010 ;21(6):617-619
Wilber,D. J.; Pappone,C.; Neuzil,P.; De Paola,A.; Marchlinski,F.; Natale,A.; Macle,L.; Daoud,E. G.; Calkins,H.; Hall,B.; Reddy,V.; Augello,G.; Reynolds,M. R.; Vinekar,C.; Liu,C. Y.; Berry,S. M.; Berry,D. A.Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial. JAMA 2010 ;303(4):333-340
WILBER,D. J.Electrophysiologic Testing for Risk Stratification Following Myocardial Infarction: Dead or Alive? Journal of cardiovascular electrophysiology 2009 ;20(8):856-858
Vasaiwala,S. C.; Finn,C.; Delpriore,J.; Leya,F.; Gagermeier,J.; Akar,J. G.; Santucci,P.; Dajani,K.; Bova,D.; Picken,M. M.; Basso,C.; Marcus,F.; Wilber,D. J.Prospective study of cardiac sarcoid mimicking arrhythmogenic right ventricular dysplasia Journal of cardiovascular electrophysiology 2009 ;20(5):473-476
Santucci,P. A.; Varma,N.; Cytron,J.; Akar,J. G.; Wilber,D. J.; Al Chekakie,M. O.; Brysiewicz,N.Electroanatomic mapping of postpacing intervals clarifies the complete active circuit and variants in atrial flutter. Heart Rhythm 2009 ;6(11):1586-1595
Poole,J. E.; Johnson,G. W.; Hellkamp,A. S.; Anderson,J.; Callans,D. J.; Raitt,M. H.; Reddy,R. K.; Marchlinski,F. E.; Yee,R.; Guarnieri,T.; Talajic,M.; Wilber,D. J.; Fishbein,D. P.; Packer,D. L.; Mark,D. B.; Lee,K. L.; Bardy,G. H.Prognostic importance of defibrillator shocks in patients with heart failure. New England Journal of Medicine 2008 ;359(10):1009-1017
Porter,M.; Spear,W.; Akar,J. G.; Helms,R.; Brysiewicz,N.; Santucci,P.; Wilber,D. J.Prospective study of atrial fibrillation termination during ablation guided by automated detection of fractionated electrograms. Journal of cardiovascular electrophysiology 2008 ;19(6):613-620
Akar,J. G.; Al Chekakie,M. O.; Fugate,T.; Moran,L.; Froloshki,B.; Varma,N.; Santucci,P.; Wilber,D. J.; Matsumura,M. E.Endothelial dysfunction in heart failure identifies responders to cardiac resynchronization therapy. Heart Rhythm 2008 ;5(9):1229-1235
Akar,J. G.; Jeske,W.; Wilber,D. J.Acute onset human atrial fibrillation is associated with local cardiac platelet activation and endothelial dysfunction. Journal of the American College of Cardiology 2008 ;51(18):1790-1793
Akar,J. G.; Singh,M.; Auseon,A. J.; Wilber,D. J.Newly diagnosed arrhythmogenic right ventricular dysplasia in an octogenarian. Journal of cardiovascular electrophysiology 2008 ;19(12):1316-1318
Blatt,J. A.; Poole,J. E.; Johnson,G. W.; Callans,D. J.; Raitt,M. H.; Reddy,R. K.; Marchlinski,F. E.; Yee,R.; Guarnieri,T.; Talajic,M.; Wilber,D. J.; Anderson,J.; Chung,K.; Wong,W. S.; Mark,D. B.; Lee,K. L.; Bardy,G. H.No benefit from defibrillation threshold testing in the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial). Journal of the American College of Cardiology 2008 ;52(7):551-556
Ramana,R. K.; Wilber,D. J.; Leya,F.Ethanol septal ablation for refractory ventricular tachycardia Journal of Invasive Cardiology 2007 ;19(5):E142-5
Al Chekakie,M. O.; Akar,J. G.; Wang,F.; Al Muradi,H.; Wu,J.; Santucci,P.; Varma,N.; Wilber,D. J.The effects of statins and renin-angiotensin system blockers on atrial fibrillation recurrence following antral pulmonary vein isolation Journal of cardiovascular electrophysiology 2007 ;18(9):942-946
Akar,J. G.; Al Chekakie,M. O.; Hai,A.; Brysiewicz,N.; Porter,M.; Varma,N.; Santucci,P.; Wilber,D. J.Surface electrocardiographic patterns and electrophysiologic characteristics of atrial flutter following modified radiofrequency MAZE procedures Journal of cardiovascular electrophysiology 2007 ;18(4):349-355
Oza,S.; Wilber,D. J.Substrate-based endocardial ablation of postinfarction ventricular tachycardia Heart Rhythm 2006 ;3(5):607-609
Daniels,D. V.; Lu,Y. Y.; Morton,J. B.; Santucci,P. A.; Akar,J. G.; Green,A.; Wilber,D. J.Idiopathic epicardial left ventricular tachycardia originating remote from the sinus of Valsalva: electrophysiological characteristics, catheter ablation, and identification from the 12-lead electrocardiogram. Circulation 2006 ;113(13):1659-1666
Azegami,K.; Wilber,D. J.; Arruda,M.; Lin,A. C.; Denman,R. A.Spatial resolution of pacemapping and activation mapping in patients with idiopathic right ventricular outflow tract tachycardia. Journal of cardiovascular electrophysiology 2005 ;16(8):823-829
Joshi,S.; Wilber,D. J.Ablation of idiopathic right ventricular outflow tract tachycardia: current perspectives Journal of cardiovascular electrophysiology 2005 ;16(Suppl 1):S52-8
Santucci,P. A.; Morton,J. B.; Picken,M. M.; Wilber,D. J.Electroanatomic mapping of the right ventricle in a patient with a giant epsilon wave, ventricular tachycardia, and cardiac sarcoidosis. Journal of cardiovascular electrophysiology 2004 ;15(9):1091-1094
Porter,M. J.; Morton,J. B.; Denman,R.; Lin,A. C.; Tierney,S.; Santucci,P. A.; Cai,J. J.; Madsen,N.; Wilber,D. J.Influence of age and gender on the mechanism of supraventricular tachycardia Heart Rhythm 2004 ;1(4):393-396
Medical School
Northwestern University Feinberg School of Medicine
Northwestern University McGaw Medical Center, Internal Medicine: General
Massachusetts General Hospital, Clinical Cardiac Electrophysiology
University of Michigan Medical Center, Cardiology
Interests & Hobbies