MAYWOOD, Ill. -- The National Institutes of Health has awarded a Loyola researcher a $1.3 million grant to study a protein that is critical for the normal functioning of the heart.
Sakthivel Sadayappan, PhD, who was awarded the four-year grant, said research at his lab has shown that during a heart attack the cardiac myosin binding protein-C breaks into pieces, and this fragmentation coincides with damage to the heart muscle that leads to heart failure.
The grant will fund further research into what happens to the protein, known as cMyBP-C, during a heart attack. This could lead to the development of drugs to protect cMyBP-C following a heart attack, and thereby limit damage to heart muscle, Sadayappan said.
The 40th anniversary of the discovery of cMyBP-C is coming up next year, and scientists still have much to learn about the function of this protein in the heart. The work by Sadayappan's lab could lead to new therapies to improve muscle function in heart failure patients.
"Our long-term goal is to delineate the roles of cMyBP-C protein function in the heart," Dr. Sadayappan said.
Loyola University Health System (LUHS) is a member of Trinity Health. Based in the western suburbs of Chicago, LUHS is a quaternary care system with a 61-acre main medical center campus, the 36-acre Gottlieb Memorial Hospital campus and more than 30 primary and specialty care facilities in Cook, Will and DuPage counties. The medical center campus is conveniently located in Maywood, 13 miles west of the Chicago Loop and 8 miles east of Oak Brook, Ill. The heart of the medical center campus, Loyola University Hospital, is a 569-licensed-bed facility. It houses a Level 1 Trauma Center, a Burn Center and the Ronald McDonald® Children’s Hospital of Loyola University Medical Center. Also on campus are the Cardinal Bernardin Cancer Center, Loyola Outpatient Center, Center for Heart & Vascular Medicine and Loyola Oral Health Center as well as the LUC Stritch School of Medicine, the LUC Marcella Niehoff School of Nursing and the Loyola Center for Fitness. Loyola's Gottlieb campus in Melrose Park includes the 264-licensed-bed community hospital, the Professional Office Building housing 150 private practice clinics, the Adult Day Care, the Gottlieb Center for Fitness, Loyola Center for Metabolic Surgery and Bariatric Care and the Loyola Cancer Care & Research at the Marjorie G. Weinberg Cancer Center at Melrose Park.