Clinical Research
This is a listing of Loyola University Health System clinical research that is open and actively recruiting patients. Please click on the name of the research for a brief description, eligibility requirements and contact information. All research listed below have been approved by Loyola's Institutional Review Board chairman for promotion on our Web site.
For more information call (888) LUHS-888.
Bladder Health
ACCESS: Abdominal Colpopexy: Comparison of Endoscopic Surgical StrategiesThis study aims to gather information about differences in outcomes between women undergoing laparoscopic sacrocolpopexy versus robotic-assisted laparoscopic sacrocolpopexy (pelvic organ prolapse repair).
Nocturia StudyFemales patients with and without nocturia (waking for nighttime urination) both with and without diabetes or chronic kidney disease, will participate by completing questionnaires, a two-day urine diary, one blood sample, one fresh urine sample, and collect urine for 24 hours to assess kidney function.
The ABC TrialMany women experience the accidental loss of urine called urge incontinence or overactive bladder (OAB) incontinence. Women describe this as a sudden, strong desire to pass urine, which results in leakage before reaching the toilet. This study compares two groups of women who each receive both an active treatment for urge incontinence and a placebo (no active drug). Treatment group one will receive a single treatment with botulinum toxin A injection in the bladder and a six-month supply of placebo pills. Treatment group two will receive a single injection of saline in the bladder (placebo) and six months of active anticholinergic medication.
Value of Bladder TestsIt is common clinical practice to perform bladder tests, called urodynamic studies (UDS), before surgery for stress urinary incontinence (the accidental loss of urine with coughing, sneezing, laughing, exercise, or similar activities). Most doctors who regularly perform incontinence surgeries order these tests. We don’t know if women who receive these tests have better outcomes than women who don’t receive them. You are being asked to participate in a research study to determine if women who have demonstrated stress urinary incontinence (the accidental loss of urine with coughing, sneezing, laughing, exercise, or similar activities) during the office evaluation have different treatment outcomes compared to women who receive both the office evaluation and urodynamic studies before stress incontinence surgery.
Cancer
A Phase III, Randomized, Placebo-controlled, Multicenter Clinical Trial to Study the Safety, Tolerability, Effectiveness and Response of V212 (Vaccine) in Individuals Receiving an Autologous Hematopoietic Cell TransplantThe purpose of this study is to assess the safety and tolerability of an inactivated vaccine of herpes zoster (varicella zoster virus) in individuals undergoing autologous transplant.
Assessment of Health Behaviors in Cancer SurvivorsTo assess the nutritional and health habits of cancer survivors.
GIDEONThe main purpose of this study is to determine the safety and effectiveness of sorafenib. How the health of participants develops while they are taking sorafenib also will be studied, as will participant satisfaction.
Treatment Therapy Followed by Umbilical Cord Stem Cell TransplantThe primary objective of this study is to measure progression free survival in the elderly at three years after umbilical cord stem cell transplantation, which may include an expanded umbilical cord stem cell unit and using pre-transplant conditioning of fludarabine, cyclophosphamide and total body irradiation.
Treatment Therapy for Acute Graft Versus Host Disease (GVHD) After an Allogeneic Stem Cell TransplantThe primary objective of this study is to find a more effective treatment for acute GVHD in people who have had an allogeneic blood stem cell transplant.
Cancer: Bladder and Urinary
A Study Comparing the Combination of Gemcitabine, Cisplatin and Bevacizumab on Transitional Cell Carcinoma of the Urinary TractThe purpose of this study is to see what effects, good and/or bad, the combination of gemcitabine, cisplatin and bevacizumab has on participants and their cancer.
Cancer: Bone
Bone Health in the Jaw of Cancer PatientsThe purpose of this study is to learn how often ONJ occurs in participants who cancer has spread to the bone and are being treated with zoledronic acid during a three-year time period after starting treatment. This study will also identify risk factors associated with ONJ.
Immune Cell Treatment in Patients with Bone CancerThe MLN1202 antibody is an immune cell from a mouse that attaches to a protein called CCR2, found on white blood cells (T-cells) in your blood and tumor. The MLN1202 antibody is being used to treat patients with rheumatoid arthritis, multiple sclerosis and scleroderma (an autoimmune disease of the skin), and these studies are ongoing. This experimental study is being conducted to see if the MLN1202 antibody is able to slow the growth of your cancer and prevent your cancer from spreading to and breaking down your bone any further.
The study will also include laboratory testing on urine and blood samples in order to find out as much as possible about your cancer and how this treatment might affect the disease.
Cancer: Bone Marrow Transplant
Treatment with New Antiviral Human Cytomegalovirus (HCMV) Drug after Allogeneic TransplantationThe primary objective of this study is to compare the safety of the study medication and the prevention of HCMV after an allogeneic transplantation with three different doses of study medication versus a placebo.
Cancer: Brain
A Phase III trial comparing the standard dose of temozolomide with a more increased, longer lasting dose of temozlomide in patients with newly diagnosed glioblastomaThe purpose of this study is to determine whether increasing the duration of temozolomide treatment after radiation from five days out of 28 days (standard-dose schedule) to 21 days out of 28 days (dose-dense schedule) will further improve results.
Chemotherapy and Radiation in Patients Newly Diagnosed With Brain CancerThe purpose of this study is to determine whether the addition of bevacizumab to the standard chemo-radiation will further improve the outcome. This study will find out what effects this change in treatment has on you and on your tumor compared with standard treatment.
Cancer: Breast
A randomized phase III study of whole breast radiation versus partial breast radiation for women with breast cancerThe purpose of this study is to see if partial breast irradiation is as good as or better than whole breast irradiation in keeping cancer from coming back in the breast.
Breast Cancer and Hormone Suppression StudyThe research is being done to determine if supressing ovary function during chemotherapy can reduce the incidence of premature menopause, which is often caused during adjuvant chemotherapy for breast cancer.
Breast Radiation Using Mammosite Brachytherapy (after breast conserving surgery)The purpose is to test whether radiation to part of the breast using brachytherapy after the removal of cancer gives similar results to those obtained when the whole breast receives radiation therapy. The study seeks to assess safety of the mammosite device in this setting, including the quality of life.
Comparing Different Chemotherapy Regimens to Treat Breast Cancer Before Having SurgeryThe purpose of this study is to compare different chemotherapy treatments and determine which is better for breast cancer patients.
Comparing Different Treatments for Breast Cancer ParticipantsThis study will determine which treatment is better for certain breast cancer participants.
Comparison of Standard Chemotherapy and Standard Chemotherapy with Investigational DrugsThe purpose of this study is to determine how women with breast cancer will respond to standard chemotherapy versus standard chemotherapy with investigational drugs.
Pathological Studies on Breast Cancer TissueThe purpose of the study is to analyze tumor specimens from breast cancer participants.
Preventing Neuropathy During Certain Breast Cancer Chemotherapy TreatmentsThe purpose of this study is to determine if the study drug prevents neuropathy of certain breast cancer chemotherapy treatments.
Recurrent Breast Cancer StudyThe purpose of this study is to determine how effective combining carboplatin, ABI-007 and bevacizumab are in the advanced breast cancer.
SOFT TrialThe purpose of this study is to see if shutting down a woman's ovaries plus giving tamoxifen is better at preventing the return of breast cancer than just giving tamoxifen alone in premenopausal women. It also will test whether a newer hormone drug called exemestane plus suppression of the ovaries is better than tamoxifen plus suppression of the ovaries. The side effects of these different treatments will be studied.
Study Between Lapatinib and Trastuzumab for Participants With Breast CancerThe main purpose of ALTTO is to find out whether lapatinib is effective in preventing cancer from returning and in extending survival in participants with HER2-positive breast cancer.
Study Comparing Radiation Therapy With or Without Trastuzumab in Women With Early Stage Breast CancerThis purpose of this study is to find out if adding trastuzumab to breast radiation therapy is more effective than radiation therapy without trastuzumab in preventing occurrence of breast cancer in the same breast, in the other breast or in other parts of the body in patients with early stage breast cancer.
Study Using Two Investigational Drugs for Breast Cancer Participants Who Have Progressed While Receiving Prior TherapyTo determine how safe and tolerable the combination of the two investigational drugs are in certain breast cancer participants.
The Effects of Trastuzumab-MCC-DM1 (T-DM1) and Pertuzumab on HER2-positive Locally Advanced or Metastatic Breast CancerThe purpose of this study is to compare the effects of T-DM1 as a single treatment versus T-DM1 combined with pertuzumab or trastuzumab combined with docetaxel or paclitaxel for the treatment of metastatic breast cancer.
The Role of Sentinel Lymph Node Dissection (SLND) Surgery and Axillary Lymph Node Dissection (ALND) Surgery after Chemotherapy in Patients with Breast CancerThe purpose of this study is to evaluate the role of SLND surgery and ALND surgery after chemotherapy in patients with breast cancer that has spread to the lymph nodes in the breast area.
The Use of BSI-201 in Combination with Chemotherapy in Patients with ER-, PR- and HER2-negative Metastatic Breast CancerThe purpose of this study is to provide BSI-201 in combination with chemotherapy to eligible patients with breast cancer and to assess the safety and side effects when the study drug is given with approved chemotherapies.
Treatment for Metastatic Breast Cancer with Anastrozole with or without FulvestrantThe purpose of this study is to determine how effective combining anastronzole with fulvestrant is compared to anastrozole alone in treating postmenopausal women with metastatic breast cancer.
Trial Comparing the Combinations of Medications Administered Prior to Breast Cancer SurgeryThe purpose of this study is to determine if combining two drugs, lapatinib and trastuzumab, with the chemotherapy drug paclitaxel before surgery increases tumor shrinkage in the breast.
Cancer: Cervical
Study Comparing Standard Radiation Therapy Treatment to an Investigational Treatment of Radiation Therapy Combined with Chemotherapy in Patients with Cervical CancerThe purpose of this study is to determine if the investigational treatment is better than the standard treatment.
Cancer: Cervical or Endometrial
Comparing Certain Chemotherapy Treatments for Cervical CancerThe purpose of this study is to determine which chemotherapy treatment results in improved overall survival.
Endometrial or Cervical Cancer Radiation Therapy StudyThe purpose of the study is to test whether the use of an advanced radiation therapy delivery technique called intensity-modulated radiation therapy (IMRT) can spare normal tissue, including small bowel and large bowel, from radiation. The research is being done to try to reduce radiation side effects (especially diarrhea) that occur with the standard radiation methods.
Cancer: Chemotherapy-Induced (CIPN)
Treatment for Pain That Arises From Injury, Disease or Dysfunction of the Nervous SystemThe purpose of this study is to find out what effects, good and/or bad, duloxetine will have and to test whether duloxetine will help reduce the amount of pain caused by peripheral neuropathy. Duloxetine will not make the peripheral neuropathy go away, but it may reduce the amount of pain caused by peripheral neuropathy.
Cancer: Colorectal
Chemotherapy (either FOLFOX or FOLFIRI) in Combination With Avastin in Patients With Locally-advanced or Metastatic Colorectal CancerThis study is being done to evaluate if pegfilgrastim is needed to stop the white blood cells from decreasing too much during your cancer treatment and to evaluate the effect, if any, of pegfilgrastim on your progression-free and overall survival.
Cancer: Gallbladder or Bile Duct
Chemotherapy and Radiation for Participants With Cancer in the Bile Duct or GallbladderThe purpose of this study is to find out what effects, good and/or bad, capecitabine, gemcitabine and radiation have on you and your cancer of the bile duct or gallbladder.
Sorafenib and Erlotinib Treatment in Individuals with Cancer of the Gallbladder or Bile DuctsThe purpose of this study is to find out what effects, good and/or bad, the combination of erlotinib and sorafenib has on you and your cancer.
Cancer: Gastric and Gastroesophageal Junct'n (GEJ)
Chemotherapy in Patients With Advanced Stomach CancerThe purpose of this study is to find out what effects GDC-0449 in combination with FOLFOX chemotherapy has on you and your gastroesophageal adenocarcinoma cancer.
Cancer: Head and Neck
Chemotherapy in Patients With Recurrent Head and Neck CancerThe purpose of this study is to compare the effects (good and bad) of the addition of bevacizumab to standard chemotherapy (cisplatin and docetaxel or cisplatin and 5-FU) and to determine if the combination of standard chemotherapy and bevacizumab can increase the effectiveness of treatment for head and neck cancer. This combination is experimental.
Cancer: Kidney (Renal)
Chemotherapy in Patients Who Have Cancer of the Kidney That Has Spread to Other Organs of the BodyThe purpose of this study is to compare the safety and effectiveness of the study drug Everolimus given before sunitinib versus sunitinib given before the study drug Everolimus, to determine the most effective order to give sunitinib and Everolimus to slow tumor growth and to determine which study treatment schedule has less side-effects.
Measurement of Bone Strength to Help Predict Bone Fracture Risk While Taking SorafenibThe purpose of this study is to measure bone strength in order to help predict bone fracture risk while taking the study drug sorafenib and to learn whether sorafenib treatment has an effect on the heart pumping blood properly.
Cancer: Leukemia
A Study Comparing the Addition of Midostaurin in the Treatment of Newly Diagnosed Patients Under 60 Years of Age With Acute Myeloid Leukemia (AML)The purpose of this study is to find out if adding midostaurin to cytarabine and daunorubicin is more effective in treating newly diagnosed acute myeloid leukemia patients under the age of 60.
A Study Comparing the Combination of Azacitidine With Entinostat for the Treatment of Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia and Acute Myeloid LeukemiaThe purpose of this study is to determine the safety and effectiveness of combining azacitidine with entinostat for myelodysplastic syndrome, chronic myelomonocytic leukemia and acute myeloid leukemia.
Leukemia Relapse TrialThe purpose of this study is to determine patient outcomes following high-dose combination chemotherapy treatment and to compare higher versus standard dose vincristine chemotherapy.
Study Combining Azacitidine With Gemtuzumab Ozogamicin for Patients With Relapsed or Refractory Acute Myeloid LeukemiaThe purpose of this study is to see what effects, good and/or bad, the investigational drug combination of hydroxyurea, azacitidine and gemtuzumab ozogamicin has on acute myeloid leukemia.
Cancer: Lung
Additional Chemotherapy Drug after surgical removal of Non Small Cell Lung CancerThe purpose of this study is to determine if adding the new drug bevacizumab to chemotherapy improves the chance for cure for patients who have had surgery for the removal of the lung cancer and to compare the effects (good and bad) of adding bevacizumab to chemotherapy compared to standard chemotherapy alone. Bevacizumab works by preventing the formation of new blood vessels, including those that surround and supply cancer cells, with the oxygen and nutrients they need to survive and grow.
Chemotherapy Agents in Patients With Lung Cancer That Has Grown Despite Earlier Treatment With ChemotherapyThe purpose of this study is to compare the effects, good and/or bad, of topotecan alone with topotecan plus AVE0005 to find out which is better. We would also like to find out more about the effects, good and/or bad, that weekly topotecan causes.
Chemotherapy in Individuals With Lung CancerThe primary objective of this study is in patients with advanced NSCLC treated with carboplatin, paclitaxel and bevacizumab (if appropriate) with or without cetuximab, to compare overall survival (OS) in the entire study population; progression-free survival (PFS) by institutional review in EGFR FISH-positive patients. The secondary objectives are in patients with advanced NSCLC treated with carboplatin, paclitaxel and bevacizumab (if appropriate) with or without cetuximab, to compare OS and PFS by centralized review in EGFR FISH-positive patients; PFS by centralized image review and by institutional review in the entire study population. To compare the response rate (confirmed plus unconfirmed, complete and partial responses) in the subset of patients with measurable disease in EGFR FISH-positive patients; the entire study population. The purpose of this study is to compare the effects, good and/or bad, of cetuximab on lung cancer.
Chemotherapy in Patients who have Advanced Lung CancerThe purpose of this study is to find out if the combination of gemcitabine plus carboplatin and BSI-201 works better than gemcitabine and carboplatin alone in patients with stage IV squamous non-small-cell lung cancer (NSCLC) that has not previously been treated. The standard chemotherapy combination contains two drugs, carboplatin and gemcitabine. In this research study, a drug called BSI-201 will be added to these two chemotherapy drugs. The combination of gemcitabine, carboplatin and BSI-201 has not been tested as a lung cancer treatment and is investigational.
Mineral Therapy After Lung Cancer SurgeryThis research is being done to study whether taking selenium (a mineral) can prevent the development of second lung cancers.
Pazopanib & weekly Paclitaxel Chemotherapy in Patients With Advanced Lung CancerThe purpose of this study is to learn about the good and bad effects of pazopanib when it is given with a chemotherapy drug called paclitaxel to treat advanced lung cancer.
Cancer: Lymphoma
A Randomized Study Using RAD001 Adjuvant Therapy Versus Placebo in Patients With Diffuse Large B-cell Lymphoma Who Have Achieved Complete Reponse With First-line Rituximab-chemotherapyThe purpose of this study is to learn if the study drug RAD001 can slow or prevent the recurrence of your cancer compared to a placebo.
Chemotherapy Treatments for Diffuse Large B-cell Lymphoma.The purpose of this study is to compare the effects (good and bad) of two treatments for lymphoma. The treatments are known as R-CHOP and DA-EPOCH-R. Another goal of the study is to analyze your tumor using new scientific laboratory studies to better understand your type of lymphoma.
Evaluation of Treatments for Newly Diagnosed Burkitt’s and Burkitt-like LymphomaThe primary objective of this study is to evaluate the effects of two different chemotherapy treatment regimens in patients with Burkitt’s and Burkitt-like lymphoma
Evaluation of Cisplatin Plus Etoposide Plus Gemcitabine Plus Solumedrol (PEGS) in Peripheral T-Cell Non-Hodgkin’s LymphomaThe purpose of this study is to find out what effects (good and bad) the combination of cisplatin, etoposide, gemcitabine, and solumdrol (PEGS) has on you and your lymphoma.
Medication Study for Relapsed Hodgkins LymphomaThis study is for people with relapsed or refractory Hodgkins lymphoma. The purpose is to see what effects (good and bad) a drug called temsirolimus has on you and your lymphoma.
Treatment Therapy Followed by Autologous Stem Cell TransplantThe primary objective of this study is to measure the level of busulfan chemotherapy and adjust the dose for each individual according to the level in the person’s blood during the preparative chemotherapies, followed by autologous hematopoietic stem cell transplant in people with Non-Hodgkin’s lymphoma and Hodgkin’s lymphoma.
Treatment Therapy Followed by Stem Cell Transplant for Relapsed Follicular Non-Hodgkin’s LymphomaThe primary objective of this study is to measure progression-free survival at two years after allogeneic hematopoietic stem cell transplantation (HSCT) using pre-transplant conditioning of fludarabine, cyclophosphamide and rituximab (FCR) for patients with relapsed follicular non-Hodgkin’s lymphoma.
Treatment Therapy for Hodgkin’s Lymphoma Patients With Disease Present After an Autologous Stem Cell TransplantThe primary objective of this study is to compare the progression-free survival of patients that have residual disease or disease that has not resolved using best supportive care with a placebo versus best supportive care with SGN-35.
Treatment Therapy to Mobilize and Collect Stem Cells for Autologous Stem Cell Transplant in Patients with Non-Hodgkin’s Lymphoma Weighing =154 lbThe primary objective of this study is to measure the number of stem cells collected for autologous stem cell transplant in patients with Non-Hodgkin’s lymphoma (NHL) using fixed dose of plerixafor in combination with G CSF as compared to the standard weight-based dose of plerixafor in combination with G CSF.
Treatment for Participants with Advanced Follicular Non-Hodgkin’s LymphomaThe purpose of the study is to evaluate your response (good and bad) of receiving R-CHOP and tositumomab followed by maintenance treatment for participants with follicular non-Hodgkin lymphoma.
Treatment of Aggressive Hodgkin Lymphoma Based on PET Scan ResultsThis study will follow PET scan results to determine if your disease is responding to standard treatment for your Hodgkin lymphoma. If it is not responding, you will be switched to a more intensive treatment plan.
Treatment of Non-Hodgkins Lymphoma for Individuals Who Have Been Previously Treated or Who are Ineligible for or Have Previously Received an Autologous Stem Cell TransplantThe purpose of this study is to see if the study drug plus rituximab is safe and if it will stop your cancer from growing or cause your cancer to shrink.
Treatment of Patients With Relapsed or Refractory CD30-positive Disease While Completing EKG/ECG MonitoringThis study is being done to test if there are any changes in the ECG/EKG of cancer patients being treated with SGN-35 (brentuximab vedotin).
Treatment of Relapsed Mantle Cell Non-Hodgkin’s Lymphoma With LenalidomideThe purpose of this study is to see what effects (good and bad) a drug called lenalidomide has on you and your lymphoma.
Treatment of relapsed or refractory ALCLThis study is being done to test if SGN-35 (treatment drug) has an effect on cancer in patients with ALCL.
Cancer: Lymphoma, Cancer: Leukemia
Umbilical Cord Blood Transplant Followed by Infusion at 24 Hours Post-Transplant of Blood Cells (Expanded Human Myeloid Progenitor Cells)The purpose of this study is to measure the safety of ex vivo expanded human myeloid progenitor cells. Expanded human myeloid progenitor cells have the ability to make red blood cells, platelets and some kinds of white blood cells.
Cancer: Multiple Myeloma
A Study Comparing the Combination of Bortezomib and Dexamethasone with Panobinostat or Placebo in Individuals with Multiple MyelomaThe purpose of this study is to find out whether the combination of panobinostat, bortezomib and dexamethasone is safe and results in a better anti-myeloma activity than bortezomib and dexamethasone alone.
A Study Investigating the Safety and Efficacy of Combining Three Chemotherapy Drugs as a Preparative Regimen for Multiple Myeloma Participants That Are Eligible for a Peripheral Blood Stem Cell TransplantThe purpose is to study the safety and efficiency of combining busulfan, melphalan and bortezomib as a preparative regimen for autologous hematopoietic stem cell transplant.
High-dose Busulfan and Melphalan followed by Bortezomib (BuMelVel) as Chemotherapy prior to Autologous Stem Cell Transplantation for Multiple MyelomaThe purpose of this study is to evaluate the effectiveness of high-dose busulfan and melphalan followed by bortezomib as chemotherapy prior to autologous stem cell transplantation for individuals with multiple myeloma and to measure the level of cells in the blood in order to evaluate disease response.
Observational Study of Patients with Monoclonal Gammopathy of Undetermined Significance (MGUS) or Asymptomatic Multiple MyelomaThe purpose of this study is to take samples of your bone marrow and blood to learn more about monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma.
Treatment Therapy Followed by Autologous Stem Cell Transplant with Relapsed Multiple Myeloma after Prior Autologous Stem CellThe primary objective of this study is to measure the response of the multiple myeloma after a second autologous stem cell transplant.
Cancer: Myelodysplastic Syndrome
A Study Comparing the Combination of Ezatiostat Hydrochloride with Lenalidomide and the Effect on Myelodysplastic Syndrome (MDS)The purpose of this study is to determine the safety, effectiveness and maximum tolerated dose of ezatiostat in combination with lenalidomide.
Cancer: Ovary, Fallopian Tube, Primary Peritoneal
A Comparison of Different Chemotherapies and Routes of Administration for Ovarian, Fallopian Tube and Primary Peritoneal CancerThe purpose of this study is to determine which chemotherapy regimen is better for the treatment of ovarian, fallopian tube and primary peritoneal cancer.
Comparing Treatments for Ovarian Cancer That Has RelapsedThe purpose of this study is to compare different treatments for ovarian cancer that has relapsed.
Cancer: Pancreatic
Chemotherapy in Patients With Pancreatic Cancer That Has Spread to Other Parts of the BodyThe purpose of this study is to determine what effects the experimental drug GDC- 0449 has on your type of cancer.
Cancer: Prostate
A Study Evaluating Early Treatment With Zoledronic Acid for Men With Prostate CancerThe purpose of this study is to determine if early treatment with zoledronic acid delays bone problems for men with prostate cancer involving the bone.
Cancer: Rectal
A Combination of Chemotherapy (Including Cetuximab), Radiation Therapy and Surgery for Participants With Stage II or III Rectal CancerThe purpose of this study is to find out what effects, good and/or bad, the combination of the chemotherapies, radiation therapy and surgery has on the participant and their rectal cancer.
Cancer: Skin (Melanoma)
Chemotherapy in Patients with Progressed MelanomaThe purpose of this study is to determine whether the new drug SCH727965 can control the growth of melanoma to a point where it can help people live longer.
Vaccine Trial for Melanoma Patients Whose Disease Has Metastasized (Stage IV).The main purpose of the study is to determine the safety of the trial's experimental procedure and the maximum dose of the vaccine that a human can tolerate. A secondary purpose is to see if the experimental procedure causes the melanoma cancer to shrink.
Cancer: Soft Tissue Sarcoma
Chemotherapy Study for Sarcoma PatientsThis study will determine the benefit of an investigational drug (AVE8062), which is an antivascular treatment that works by destroying the small vessels that feed the tumor with blood, for patients with soft-tissue sarcoma whose treatments with anthracycline and ifosfamide have failed.
Cancer: Uterine
Comparison of a Combination of Chemotherapy Drugs to the Standard Chemotherapy Treatment for Uterine CancerThe purpose of this study is to compare a different chemotherapy combination with the current standard chemotherapy treatment for uterine cancer.
Study Comparing Standard Radiation Therapy Treatment to an Investigational Treatment of Radiation Therapy Combined with Chemotherapy in Patients with Endometrial (Uterine) CancerThe purpose of this study is to determine if the study treatment is more effective than the standard treatment of uterine cancer.
Cardiovadiovascular Health: Arrhythmia
Multidisciplinary Study of Right Ventricular Dysplasia (ARVD)This is a multidisciplinary, multicenter collaborative study to investigate the cardiac, clinical and genetic aspects of arrhythmogenic right ventricular dysplasia (ARVD). The primary goal is to identify 100 patients with definite ARVD and their family members. The study offers a substantial prospect of expanding the fund of clinical knowledge regarding ARVD and/or localizing the genetic mutation(s) responsible for this disorder.
Cardiovascular
SELECT-AFThe purpose of this study is to compare two different computer strategies to identify abnormal signals in the atrium for ablation that are not around the pulmonary veins.
Cardiovascular Health
CABANA TrialAtrial fibrillation is an abnormal, rapid heart rhythm coming from the upper chambers of the heart (atria). Atrial fibrillation is the most common type of heart rhythm disorder. Instead of the heart beating in a steady pattern, in atrial fibrillation the upper chambers of the heart quiver rapidly in an unsteady manner. Atrial fibrillation may be treated with drug therapy designed to either prevent the heart rate from going too fast, or with drug therapy designed to maintain normal heart beating. In some institutions, atrial fibrillation also is treated with catheters inserted into blood vessels that can be placed inside the heart to eliminate the hot spots or triggers that start atrial fibrillation (catheter ablation). It is not known whether drug therapy or catheter ablation is better.
The Catheter Ablation Versus Anti-arrhythmic Drug Therapy for Atrial Fibrillation (CABANA) study is being done to compare drug therapy and catheter ablation in patients with atrial fibrillation. This study will help decide which treatment approach is best or when one or the other therapy is preferred. The CABANA study also will compare the cost of care for the two treatment approaches and determine the effect these therapies have on quality of life.
Cardiovascular Health: Aortic Aneurysm
Descending Thoracic Aorta Aneurysm Stent StudyThe purpose of this research study is to determine if the study device is safe and effective when used to treat aneurysms of the descending thoracic aorta.
PRICELESSAt the time of endovascular aortic aneurysm repair surgery, a pressure-sensing device will be implanted in the aneurysm. It is permanently placed in the aneurysm sac and measures the pressure in the sac during the repair. Measurement readings from the sensor are painless and made with a device containing an antenna positioned over the abdomen.
It is believed that sensor measurements may be a useful addition to other tests that are used to measure the sac size and detect leaks from endovascular grafts.
The purpose of this research is to collect and compare sensor data with data from CT scan imaging and other diagnostic methods used in patients who have had a repair of the aneurysm.
Stent Graft for the Repair of Abdominal Aortic Aneurysms StudyThe purpose of this research study is to determine if the study stent is safe and effective when used to treat abdominal aortic aneurysms in patients who are not candidates for repair with commercially available stents and are high risk for conventional surgical repair.
Cardiovascular Health: Heart Failure
Double-Blind, Placebo-Controlled, Multicenter Acute Study of Clinical Effectiveness of Nesiritede in Subjects with Decompensated Heart Failure (ASCEND-HF)This study is being done to find out if the drug that is being researched, nesiritide (tradename Natrecor®)? as compared to placebo (pill with an inactive substance which looks like the real drug), plus the usual treatment for acute decompensated heart failure (standard of care) helps:· improve your breathing difficulties· reduce the chance that you will be readmitted to the hospital· patients live longer
Cardiovascular Health: Paroxysmal Atrial Fibr'tn
SELECT-AFThe purpose of this study is to compare two different computer strategies to identify abnormal signals in the atrium for ablation that are not around the pulmonary veins.
Cardiovascular: Marfan Syndrome
Aortic Valve Surgery in Marfan PatientsThe purpose of the trial is to collect information on how patients do after having surgery on their aortic valve and compare the results of those who had their valve replaced to those who had the valve repaired.
Endocrinology: Diabetes
The Sunshine StudyThe purpose of this study is to determine whether taking vitamin D supplementation will help with control of blood sugar and with improving mood.
Endocrinology: Growth Hormone
Growth Hormone Deficiency StudyThe purpose of the study is to compare long-term health outcomes in patients who are lacking adult growth hormones.
Mental Health: Depression
Endothelial Function in Depressed PatientsThe purpose of this study is to determine whether depressed individuals show signs of dysfunction in their blood vessels.
Quetiapine May Lower Cardiovascular Risk Due to Depression and AnxietyThe purpose of this study is to determine if quetiapine can reverse the arterial stiffening that often occurs in depression and anxiety, which are believed to be risk factors for future heart disease.
Arterial stiffness will be measured non-invasively by a procedure called applanation tonometry. The measures serve as markers of subclinical hardening of the arteries and may be able to show a response to therapy, if such hardening is present. The procedure involves positioning of a probe on the skin overlaying certain arteries in the body, namely the radial, carotid and femoral. Heart rate variability similarly is determined non-invasively by placing three leads on the chest and determining heart function. Treatment with quetiapine may restore normal heart function.
Neurology: Arterio-vascular Malformation
ARUBAAn arteriovenous malformation (AVM), which has not ruptured, may rupture and cause death or stroke. The purpose of this study is to determine if an intervention is better for treating the symptoms (such as headache).
Neurosciences
Quetiapine May Lower Cardiovascular Risk Due to Depression and AnxietyTo determine if quetiapine treatment of depression and anxiety can reverse the arterial stiffening that often occurs in depression and anxiety, which are believed to be risk factors for future heart disease.
Pulmonary: Cystic Fibrosis
Cystic Fibrosis StudyThe purpose of this study, which involves research, is to determine the safety and effectiveness of an experimental drug/device combination, a dry powder inhaler with ciprofloxacin, in the treatment of this disease, compared with placebo (an inactive substance).
Skin Health: Psoriasis
ESPIRIT registry study for psoriasisThe purpose of this registry is to observe the degree of long-term safety of adalimumab and how well it works to treat chronic plaque psoriasis for up to 10 years. Adalimumab is a marketed drug for psoriasis. No medication is provided for this registry. Your doctor will give you a prescription for adalimumab.
Etanercept Psoriasis RegistryThe purpose of this study is to continue to gather and evaluate information on the long-term safety of etanercept in a large number of patients with plaque psoriasis.
PSOLAR Registry Study for PsoriasisThe registry study will track the behavior of the disease in response to other therapies, such as adalimumab, alefacept, certolizumab pegol, efalizumab, etanercept and other biologics. The registry also will evaluate clinical outcomes, quality of life and potential risks for participants who may receive standard therapies for psoriasis.
Stroke
ALIAS - Albumin in acute strokeMany stroke studies have been performed looking for an effective treatment for patients who have suffered an acute ischemic stroke. Thus far, all have failed. This study seeks to determine the effectiveness of albumin versus placebo given intravaenously for stroke patients.
IRIS: Insulin Resistance Intervention After Stroke TrialBoth stroke and heart attack are serious medical problems. The purpose of this study is to see if stroke and heart attack can be reduced in insulin resistant non-diabetic adults using an approved drug versus a placebo (inactive drug).
The Experience of Female Caregivers of Stroke SurvivorsThe purpose of this study is to describe how female caregivers of stroke survivors cope with the stress of care-giving.
Transplant: Lung
Investigational Medication to Help Prevent Rejection after Lung TransplantationThe purpose of this research study is to assess whether or not inhaled cyclosporine (CIS), in addition to other medications that suppress the immune system, will help to prevent the new lung(s) from being rejected by the body’s natural defense system.
Lung Transplant: Does Cyclosporine Inhaled Solution Help Prevent the Rejection?The purpose of this study is to determine whether inhaled cyclosporine (CIS), in addition to other medications that put down the immune system, helps prevent a new lung(s) transplant from being rejected by the body’s natural defense system.
Respiratory Syncytial Virus (RSV) StudyThis purpose of this study is to determine the effects (both good and bad) of ALN RSV01 for the treatment of RSV.
Women's Health: Prolapse and Bladder Control
The OPTIMAL TrialThe OPTIMAL study has two purposes: 1) compare two standard vaginal surgical techniques; and 2) see if patients do better when they receive pelvic muscle exercises and behavioral instructions around the time of surgery.