Cancer Clinical Research
This is a listing of Loyola University Health System Cancer clinical research that is open and actively recruiting patients. Please click on the name of the research for a brief description, eligibility requirements and contact information. All research listed below have been approved by Loyola's Institutional Review Board chairman for promotion on our Web site.
For more information call (888) LUHS-888.
Cancer
Assessment of Health Behaviors in Cancer SurvivorsTo assess the nutritional and health habits of cancer survivors.
GIDEONThe main purpose of this study is to determine the safety and effectiveness of sorafenib. How the health of participants develops while they are taking sorafenib also will be studied, as will participant satisfaction.
Treatment Therapy Followed by Umbilical Cord Stem Cell TransplantThe primary objective of this study is to measure progression free survival in the elderly at three years after umbilical cord stem cell transplantation, which may include an expanded umbilical cord stem cell unit and using pre-transplant conditioning of fludarabine, cyclophosphamide and total body irradiation.
Treatment Therapy for Acute Graft Versus Host Disease (GVHD) After an Allogeneic Stem Cell TransplantThe primary objective of this study is to find a more effective treatment for acute GVHD in people who have had an allogeneic blood stem cell transplant.
Cancer: Bladder and Urinary
A Study Comparing the Combination of Gemcitabine, Cisplatin and Bevacizumab on Transitional Cell Carcinoma of the Urinary TractThe purpose of this study is to see what effects, good and/or bad, the combination of gemcitabine, cisplatin and bevacizumab has on participants and their cancer.
Cancer: Bone
Bone Health in the Jaw of Cancer PatientsThe purpose of this study is to learn how often ONJ occurs in participants who cancer has spread to the bone and are being treated with zoledronic acid during a three-year time period after starting treatment. This study will also identify risk factors associated with ONJ.
Immune Cell Treatment in Patients with Bone CancerThe MLN1202 antibody is an immune cell from a mouse that attaches to a protein called CCR2, found on white blood cells (T-cells) in your blood and tumor. The MLN1202 antibody is being used to treat patients with rheumatoid arthritis, multiple sclerosis and scleroderma (an autoimmune disease of the skin), and these studies are ongoing. This experimental study is being conducted to see if the MLN1202 antibody is able to slow the growth of your cancer and prevent your cancer from spreading to and breaking down your bone any further.
The study will also include laboratory testing on urine and blood samples in order to find out as much as possible about your cancer and how this treatment might affect the disease.
Cancer: Bone Marrow Transplant
Treatment with New Antiviral Human Cytomegalovirus (HCMV) Drug after Allogeneic TransplantationThe primary objective of this study is to compare the safety of the study medication and the prevention of HCMV after an allogeneic transplantation with three different doses of study medication versus a placebo.
Cancer: Brain
A Phase III trial comparing the standard dose of temozolomide with a more increased, longer lasting dose of temozlomide in patients with newly diagnosed glioblastomaThe purpose of this study is to determine whether increasing the duration of temozolomide treatment after radiation from five days out of 28 days (standard-dose schedule) to 21 days out of 28 days (dose-dense schedule) will further improve results.
Chemotherapy and Radiation in Patients Newly Diagnosed With Brain CancerThe purpose of this study is to determine whether the addition of bevacizumab to the standard chemo-radiation will further improve the outcome. This study will find out what effects this change in treatment has on you and on your tumor compared with standard treatment.
Cancer: Breast
A randomized phase III study of whole breast radiation versus partial breast radiation for women with breast cancerThe purpose of this study is to see if partial breast irradiation is as good as or better than whole breast irradiation in keeping cancer from coming back in the breast.
Breast Cancer and Hormone Suppression StudyThe research is being done to determine if supressing ovary function during chemotherapy can reduce the incidence of premature menopause, which is often caused during adjuvant chemotherapy for breast cancer.
Breast Radiation Using Mammosite Brachytherapy (after breast conserving surgery)The purpose is to test whether radiation to part of the breast using brachytherapy after the removal of cancer gives similar results to those obtained when the whole breast receives radiation therapy. The study seeks to assess safety of the mammosite device in this setting, including the quality of life.
Comparing Different Chemotherapy Regimens to Treat Breast Cancer Before Having SurgeryThe purpose of this study is to compare different chemotherapy treatments and determine which is better for breast cancer patients.
Comparing Different Regimens to Treat Breast Cancer Before SurgeryThe purpose of this study is to learn how breast cancer tumors respond to several different chemotherapy combinations.
Comparing Different Treatments for Breast Cancer ParticipantsThis study will determine which treatment is better for certain breast cancer participants.
Comparison of Standard Chemotherapy and Standard Chemotherapy with Investigational DrugsThe purpose of this study is to determine how women with breast cancer will respond to standard chemotherapy versus standard chemotherapy with investigational drugs.
Pathological Studies on Breast Cancer TissueThe purpose of the study is to analyze tumor specimens from breast cancer participants.
Preventing Neuropathy During Certain Breast Cancer Chemotherapy TreatmentsThe purpose of this study is to determine if the study drug prevents neuropathy of certain breast cancer chemotherapy treatments.
Recurrent Breast Cancer StudyThe purpose of this study is to determine how effective combining carboplatin, ABI-007 and bevacizumab are in the advanced breast cancer.
SOFT TrialThe purpose of this study is to see if shutting down a woman's ovaries plus giving tamoxifen is better at preventing the return of breast cancer than just giving tamoxifen alone in premenopausal women. It also will test whether a newer hormone drug called exemestane plus suppression of the ovaries is better than tamoxifen plus suppression of the ovaries. The side effects of these different treatments will be studied.
Study Between Lapatinib and Trastuzumab for Participants With Breast CancerThe main purpose of ALTTO is to find out whether lapatinib is effective in preventing cancer from returning and in extending survival in participants with HER2-positive breast cancer.
Study Comparing Radiation Therapy With or Without Trastuzumab in Women With Early Stage Breast CancerThis purpose of this study is to find out if adding trastuzumab to breast radiation therapy is more effective than radiation therapy without trastuzumab in preventing occurrence of breast cancer in the same breast, in the other breast or in other parts of the body in patients with early stage breast cancer.
Study Using Two Investigational Drugs for Breast Cancer Participants Who Have Progressed While Receiving Prior TherapyTo determine how safe and tolerable the combination of the two investigational drugs are in certain breast cancer participants.
The Role of Sentinel Lymph Node Dissection (SLND) Surgery and Axillary Lymph Node Dissection (ALND) Surgery after Chemotherapy in Patients with Breast CancerThe purpose of this study is to evaluate the role of SLND surgery and ALND surgery after chemotherapy in patients with breast cancer that has spread to the lymph nodes in the breast area.
The Use of BSI-201 in Combination with Chemotherapy in Patients with ER-, PR- and HER2-negative Metastatic Breast CancerThe purpose of this study is to provide BSI-201 in combination with chemotherapy to eligible patients with breast cancer and to assess the safety and side effects when the study drug is given with approved chemotherapies.
Treatment for Metastatic Breast Cancer with Anastrozole with or without FulvestrantThe purpose of this study is to determine how effective combining anastronzole with fulvestrant is compared to anastrozole alone in treating postmenopausal women with metastatic breast cancer.
Trial Comparing the Combinations of Medications Administered Prior to Breast Cancer SurgeryThe purpose of this study is to determine if combining two drugs, lapatinib and trastuzumab, with the chemotherapy drug paclitaxel before surgery increases tumor shrinkage in the breast.
Cancer: Cervical or Endometrial
Comparing Certain Chemotherapy Treatments for Cervical CancerThe purpose of this study is to determine which chemotherapy treatment results in improved overall survival.
Endometrial or Cervical Cancer Radiation Therapy StudyThe purpose of the study is to test whether the use of an advanced radiation therapy delivery technique called intensity-modulated radiation therapy (IMRT) can spare normal tissue, including small bowel and large bowel, from radiation. The research is being done to try to reduce radiation side effects (especially diarrhea) that occur with the standard radiation methods.
Cancer: Chemotherapy-Induced (CIPN)
Treatment for Pain That Arises From Injury, Disease or Dysfunction of the Nervous SystemThe purpose of this study is to find out what effects, good and/or bad, duloxetine will have and to test whether duloxetine will help reduce the amount of pain caused by peripheral neuropathy. Duloxetine will not make the peripheral neuropathy go away, but it may reduce the amount of pain caused by peripheral neuropathy.
Cancer: Colorectal
Chemotherapy (either FOLFOX or FOLFIRI) in Combination With Avastin in Patients With Locally-advanced or Metastatic Colorectal CancerThis study is being done to evaluate if pegfilgrastim is needed to stop the white blood cells from decreasing too much during your cancer treatment and to evaluate the effect, if any, of pegfilgrastim on your progression-free and overall survival.
Cancer: Gallbladder or Bile Duct
Chemotherapy and Radiation for Participants With Cancer in the Bile Duct or GallbladderThe purpose of this study is to find out what effects, good and/or bad, capecitabine, gemcitabine and radiation have on you and your cancer of the bile duct or gallbladder.
Sorafenib and Erlotinib Treatment in Individuals with Cancer of the Gallbladder or Bile DuctsThe purpose of this study is to find out what effects, good and/or bad, the combination of erlotinib and sorafenib has on you and your cancer.
Cancer: Gastric and Gastroesophageal Junct'n (GEJ)
Chemotherapy in Patients With Advanced Stomach CancerThe purpose of this study is to find out what effects GDC-0449 in combination with FOLFOX chemotherapy has on you and your gastroesophageal adenocarcinoma cancer.
Cancer: Head and Neck
Chemotherapy in Patients With Recurrent Head and Neck CancerThe purpose of this study is to compare the effects (good and bad) of the addition of bevacizumab to standard chemotherapy (cisplatin and docetaxel or cisplatin and 5-FU) and to determine if the combination of standard chemotherapy and bevacizumab can increase the effectiveness of treatment for head and neck cancer. This combination is experimental.
Cancer: Kidney (Renal)
Chemotherapy in Patients Who Have Cancer of the Kidney That Has Spread to Other Organs of the BodyThe purpose of this study is to compare the safety and effectiveness of the study drug Everolimus given before sunitinib versus sunitinib given before the study drug Everolimus, to determine the most effective order to give sunitinib and Everolimus to slow tumor growth and to determine which study treatment schedule has less side-effects.
Measurement of Bone Strength to Help Predict Bone Fracture Risk While Taking SorafenibThe purpose of this study is to measure bone strength in order to help predict bone fracture risk while taking the study drug sorafenib and to learn whether sorafenib treatment has an effect on the heart pumping blood properly.
Cancer: Leukemia
A Study Comparing the Addition of Midostaurin in the Treatment of Newly Diagnosed Patients Under 60 Years of Age With Acute Myeloid Leukemia (AML)The purpose of this study is to find out if adding midostaurin to cytarabine and daunorubicin is more effective in treating newly diagnosed acute myeloid leukemia patients under the age of 60.
A Study Comparing the Combination of Azacitidine With Entinostat for the Treatment of Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia and Acute Myeloid LeukemiaThe purpose of this study is to determine the safety and effectiveness of combining azacitidine with entinostat for myelodysplastic syndrome, chronic myelomonocytic leukemia and acute myeloid leukemia.
Leukemia Relapse TrialThe purpose of this study is to determine patient outcomes following high-dose combination chemotherapy treatment and to compare higher versus standard dose vincristine chemotherapy.
Study Combining Azacitidine With Gemtuzumab Ozogamicin for Patients With Relapsed or Refractory Acute Myeloid LeukemiaThe purpose of this study is to see what effects, good and/or bad, the investigational drug combination of hydroxyurea, azacitidine and gemtuzumab ozogamicin has on acute myeloid leukemia.
Cancer: Lung
Additional Chemotherapy Drug after surgical removal of Non Small Cell Lung CancerThe purpose of this study is to determine if adding the new drug bevacizumab to chemotherapy improves the chance for cure for patients who have had surgery for the removal of the lung cancer and to compare the effects (good and bad) of adding bevacizumab to chemotherapy compared to standard chemotherapy alone. Bevacizumab works by preventing the formation of new blood vessels, including those that surround and supply cancer cells, with the oxygen and nutrients they need to survive and grow.
Chemotherapy Agents in Patients With Lung Cancer That Has Grown Despite Earlier Treatment With ChemotherapyThe purpose of this study is to compare the effects, good and/or bad, of topotecan alone with topotecan plus AVE0005 to find out which is better. We would also like to find out more about the effects, good and/or bad, that weekly topotecan causes.
Chemotherapy in Individuals With Lung CancerThe primary objective of this study is in patients with advanced NSCLC treated with carboplatin, paclitaxel and bevacizumab (if appropriate) with or without cetuximab, to compare overall survival (OS) in the entire study population; progression-free survival (PFS) by institutional review in EGFR FISH-positive patients. The secondary objectives are in patients with advanced NSCLC treated with carboplatin, paclitaxel and bevacizumab (if appropriate) with or without cetuximab, to compare OS and PFS by centralized review in EGFR FISH-positive patients; PFS by centralized image review and by institutional review in the entire study population. To compare the response rate (confirmed plus unconfirmed, complete and partial responses) in the subset of patients with measurable disease in EGFR FISH-positive patients; the entire study population. The purpose of this study is to compare the effects, good and/or bad, of cetuximab on lung cancer.
Chemotherapy in Patients With Advanced Lung CancerThe purpose of the first part of this study is to test the safety of pazopanib when it is given with paclitaxel at different doses to treat advanced cancer. This part of the study will decide which dose of pazopanib and which dose of paclitaxel should be used in the second part of the study. The purpose of the second part of the study is to test the safety of pazopanib plus paclitaxel and how well it works to treat advanced lung cancer. Pazopanib plus paclitaxel will be compared with paclitaxel plus carboplatin; these drugs are often used to treat advanced lung cancer.
Chemotherapy in Patients who have Advanced Lung CancerThe purpose of this study is to find out if the combination of gemcitabine plus carboplatin and BSI-201 works better than gemcitabine and carboplatin alone in patients with stage IV squamous non-small-cell lung cancer (NSCLC) that has not previously been treated. The standard chemotherapy combination contains two drugs, carboplatin and gemcitabine. In this research study, a drug called BSI-201 will be added to these two chemotherapy drugs. The combination of gemcitabine, carboplatin and BSI-201 has not been tested as a lung cancer treatment and is investigational.
Mineral Therapy After Lung Cancer SurgeryThis research is being done to study whether taking selenium (a mineral) can prevent the development of second lung cancers.
Cancer: Lymphoma
A Randomized Study Using RAD001 Adjuvant Therapy Versus Placebo in Patients With Diffuse Large B-cell Lymphoma Who Have Achieved Complete Reponse With First-line Rituximab-chemotherapyThe purpose of this study is to learn if the study drug RAD001 can slow or prevent the recurrence of your cancer compared to a placebo.
Chemotherapy Treatments for Diffuse Large B-cell Lymphoma.The purpose of this study is to compare the effects (good and bad) of two treatments for lymphoma. The treatments are known as R-CHOP and DA-EPOCH-R. Another goal of the study is to analyze your tumor using new scientific laboratory studies to better understand your type of lymphoma.
Evaluation of Treatments for Newly Diagnosed Burkitt’s and Burkitt-like LymphomaThe primary objective of this study is to evaluate the effects of two different chemotherapy treatment regimens in patients with Burkitt’s and Burkitt-like lymphoma
Evaluation of Cisplatin Plus Etoposide Plus Gemcitabine Plus Solumedrol (PEGS) in Peripheral T-Cell Non-Hodgkin’s LymphomaThe purpose of this study is to find out what effects (good and bad) the combination of cisplatin, etoposide, gemcitabine, and solumdrol (PEGS) has on you and your lymphoma.
Medication Study for Relapsed Hodgkins LymphomaThis study is for people with relapsed or refractory Hodgkins lymphoma. The purpose is to see what effects (good and bad) a drug called temsirolimus has on you and your lymphoma.
Treatment Therapy Followed by Autologous Stem Cell TransplantThe primary objective of this study is to measure the level of busulfan chemotherapy and adjust the dose for each individual according to the level in the person’s blood during the preparative chemotherapies, followed by autologous hematopoietic stem cell transplant in people with Non-Hodgkin’s lymphoma and Hodgkin’s lymphoma.
Treatment Therapy Followed by Stem Cell Transplant for Relapsed Follicular Non-Hodgkin’s LymphomaThe primary objective of this study is to measure progression-free survival at two years after allogeneic hematopoietic stem cell transplantation (HSCT) using pre-transplant conditioning of fludarabine, cyclophosphamide and rituximab (FCR) for patients with relapsed follicular non-Hodgkin’s lymphoma.
Treatment Therapy for Hodgkin’s Lymphoma Patients With Disease Present After an Autologous Stem Cell TransplantThe primary objective of this study is to compare the progression-free survival of patients that have residual disease or disease that has not resolved using best supportive care with a placebo versus best supportive care with SGN-35.
Treatment Therapy to Mobilize and Collect Stem Cells for Autologous Stem Cell Transplant in Patients with Non-Hodgkin’s Lymphoma Weighing =154 lbThe primary objective of this study is to measure the number of stem cells collected for autologous stem cell transplant in patients with Non-Hodgkin’s lymphoma (NHL) using fixed dose of plerixafor in combination with G CSF as compared to the standard weight-based dose of plerixafor in combination with G CSF.
Treatment for Participants with Advanced Follicular Non-Hodgkin’s LymphomaThe purpose of the study is to evaluate your response (good and bad) of receiving R-CHOP and tositumomab followed by maintenance treatment for participants with follicular non-Hodgkin lymphoma.
Treatment of Aggressive Hodgkin Lymphoma Based on PET Scan ResultsThis study will follow PET scan results to determine if your disease is responding to standard treatment for your Hodgkin lymphoma. If it is not responding, you will be switched to a more intensive treatment plan.
Treatment of Non-Hodgkins Lymphoma for Individuals Who Have Been Previously Treated or Who are Ineligible for or Have Previously Received an Autologous Stem Cell TransplantThe purpose of this study is to see if the study drug plus rituximab is safe and if it will stop your cancer from growing or cause your cancer to shrink.
Treatment of Patients With Relapsed or Refractory CD30-positive Disease While Completing EKG/ECG MonitoringThis study is being done to test if there are any changes in the ECG/EKG of cancer patients being treated with SGN-35 (brentuximab vedotin).
Treatment of Relapsed Mantle Cell Non-Hodgkin’s Lymphoma With LenalidomideThe purpose of this study is to see what effects (good and bad) a drug called lenalidomide has on you and your lymphoma.
Treatment of Relapsed or Refractory CD30-positive Disease While Completing EKG/ECG MonitoringThis study is being done to test if there are any changes in the ECG/EKG of cancer patients being treated with SGN-35 (brentuximab vedotin).
Treatment of relapsed or refractory ALCLThis study is being done to test if SGN-35 (treatment drug) has an effect on cancer in patients with ALCL.
Cancer: Multiple Myeloma
A Study Comparing the Combination of Bortezomib and Dexamethasone with Panobinostat or Placebo in Individuals with Multiple MyelomaThe purpose of this study is to find out whether the combination of panobinostat, bortezomib and dexamethasone is safe and results in a better anti-myeloma activity than bortezomib and dexamethasone alone.
A Study Investigating the Safety and Efficacy of Combining Three Chemotherapy Drugs as a Preparative Regimen for Multiple Myeloma Participants That Are Eligible for a Peripheral Blood Stem Cell TransplantThe purpose is to study the safety and efficiency of combining busulfan, melphalan and bortezomib as a preparative regimen for autologous hematopoietic stem cell transplant.
Observational Study of Patients with Monoclonal Gammopathy of Undetermined Significance (MGUS) or Asymptomatic Multiple MyelomaThe purpose of this study is to take samples of your bone marrow and blood to learn more about monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma.
Treatment Therapy Followed by Autologous Stem Cell Transplant with Relapsed Multiple Myeloma after Prior Autologous Stem CellThe primary objective of this study is to measure the response of the multiple myeloma after a second autologous stem cell transplant.
Cancer: Myelodysplastic Syndrome
A Study Comparing the Combination of Ezatiostat Hydrochloride with Lenalidomide and the Effect on Myelodysplastic Syndrome (MDS)The purpose of this study is to determine the safety, effectiveness and maximum tolerated dose of ezatiostat in combination with lenalidomide.
Cancer: Ovary, Fallopian Tube, Primary Peritoneal
A Comparison of Different Chemotherapies and Routes of Administration for Ovarian, Fallopian Tube and Primary Peritoneal CancerThe purpose of this study is to determine which chemotherapy regimen is better for the treatment of ovarian, fallopian tube and primary peritoneal cancer.
Comparing Treatments for Ovarian Cancer That Has RelapsedThe purpose of this study is to compare different treatments for ovarian cancer that has relapsed.
Cancer: Pancreatic
Chemotherapy in Patients With Pancreatic Cancer That Has Spread to Other Parts of the BodyThe purpose of this study is to determine what effects the experimental drug GDC- 0449 has on your type of cancer.
Cancer: Prostate
A Study Evaluating Early Treatment With Zoledronic Acid for Men With Prostate CancerThe purpose of this study is to determine if early treatment with zoledronic acid delays bone problems for men with prostate cancer involving the bone.
Cancer: Rectal
A Combination of Chemotherapy (Including Cetuximab), Radiation Therapy and Surgery for Participants With Stage II or III Rectal CancerThe purpose of this study is to find out what effects, good and/or bad, the combination of the chemotherapies, radiation therapy and surgery has on the participant and their rectal cancer.
Cancer: Skin (Melanoma)
Chemotherapy in Patients with Progressed MelanomaThe purpose of this study is to determine whether the new drug SCH727965 can control the growth of melanoma to a point where it can help people live longer.
Vaccine Trial for Melanoma Patients Whose Disease Has Metastasized (Stage IV).The main purpose of the study is to determine the safety of the trial's experimental procedure and the maximum dose of the vaccine that a human can tolerate. A secondary purpose is to see if the experimental procedure causes the melanoma cancer to shrink.
Cancer: Soft Tissue Sarcoma
Chemotherapy Study for Sarcoma PatientsThis study will determine the benefit of an investigational drug (AVE8062), which is an antivascular treatment that works by destroying the small vessels that feed the tumor with blood, for patients with soft-tissue sarcoma whose treatments with anthracycline and ifosfamide have failed.
Cancer: Uterine
Comparison of a Combination of Chemotherapy Drugs to the Standard Chemotherapy Treatment for Uterine CancerThe purpose of this study is to compare a different chemotherapy combination with the current standard chemotherapy treatment for uterine cancer.
Cardiovascular Health: Heart Failure
Double-Blind, Placebo-Controlled, Multicenter Acute Study of Clinical Effectiveness of Nesiritede in Subjects with Decompensated Heart Failure (ASCEND-HF)This study is being done to find out if the drug that is being researched, nesiritide (tradename Natrecor®)? as compared to placebo (pill with an inactive substance which looks like the real drug), plus the usual treatment for acute decompensated heart failure (standard of care) helps:· improve your breathing difficulties· reduce the chance that you will be readmitted to the hospital· patients live longer
Transplant: Lung
Lung Transplant: Does Cyclosporine Inhaled Solution Help Prevent the Rejection?The purpose of this study is to determine whether inhaled cyclosporine (CIS), in addition to other medications that put down the immune system, helps prevent a new lung(s) transplant from being rejected by the body’s natural defense system.